| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
Purity: ≥98%
Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.
| ln Vitro |
Radiolabeled selamectin was found to be a P-glycoprotein (P-gp) substrate with a secretion/absorption ratio of 4.7 when it was transported across the Caco-2 monolayer. In peripheral blood lymphocytes (PBL), selamectin inhibits Rh-123 efflux at a dose that is comparable to verapamil's inhibitory effect [2].
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| ln Vivo |
B can be successfully avoided with topical selamectin 6 mg/kg once every two months. infection in cats with malayi. Twice a year, topical selamectin can stop microfilariae from circulating [1].
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| References |
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| Additional Infomation |
Selamectin is a milbemycin class of drugs. Selamectin is a topical anthelmintic used to treat and prevent heartworm, flea, ear mite, scabies, and certain tick infections in dogs and cats, and to prevent heartworm, flea, ear mite, hookworm, and roundworm infections in cats. It can also eliminate two lungworms in cats and one in dogs. This drug is distributed by Zoetis, a former subsidiary of Pfizer. Its structure is related to ivermectin and milbemycin. Selamectin is not approved for human use. See also: Salorana; Selamectin (ingredients). Indications: Cats and dogs: For the treatment and prevention of flea infestations caused by the genus Ctenocephalides after a single dose, with effects lasting one month. This is due to the product's adult, larval, and ovicidal properties. The product retains its ovicidal effect for up to 3 weeks after administration. By reducing flea populations, monthly treatment of pregnant and lactating animals also helps prevent flea infestation in puppies before 7 weeks of age. This product can be used as part of a flea allergy dermatitis treatment regimen; its ovicidal and larval-killing effects help control existing environmental flea infestations in areas accessible to the animal. Monthly administration can prevent canine heartworm disease caused by Dirofilaria immitis. This product is safe for use in animals already infected with adult worms; however, according to good veterinary practice, it is recommended that all animals aged 6 months and older living in countries with vectors be tested for adult Dirofilaria immitis infection before starting this product. Even with monthly use of this product, regular testing for adult Dirofilaria immitis infection in dogs is recommended as an important part of a heartworm prevention strategy. This product is ineffective against adult Dirofilaria immitis. Used to treat ear mites (Otodectes cynotis). Cats: Used to treat cat fleas (Felicola subrostratus), adult roundworms (Toxocara cati), adult hookworms (Ancylostoma tubaeforme), cat fleas (Trichodectes canis), and scabies (caused by Sarcoptes scabiei). A single dose can treat and prevent flea infestations caused by Ctenocephalides spp., with effects lasting up to one month. This is due to the product's adult, larval, and ovicidal properties. The product retains its ovicidal effect for up to three weeks after administration. Monthly treatment of pregnant and lactating animals by reducing flea populations also helps prevent flea infestations in pups before seven weeks of age. This product can be used as part of a flea allergy dermatitis treatment regimen; its ovicidal and larval-killing effects help control existing environmental flea infestations in the animal's living area. Monthly administration can prevent canine heartworm disease caused by Dirofilaria immitis. This product is safe for use in animals already infected with adult canine heartworms. However, according to good veterinary practice, it is recommended that all animals aged 6 months and older living in countries with vectors be tested for adult canine heartworm infection before starting this product. Even with monthly administration, regular testing for adult canine heartworm infection in dogs is recommended as an important part of a canine heartworm prevention strategy. This product is ineffective against adult canine heartworms. It is used to treat ear mites (Otodectes cynotis). Cats: Treatment of feline fleas (Felicola subrostratus); treatment of adult feline toxocara cati; treatment of adult canine hookworm (Ancylostoma tubaeforme). Dogs: Treatment of canine fleas (Trichodectes canis); treatment of scabies (caused by Sarcoptes scabiei); treatment of adult canine toxocara canis.
Cats and Dogs: A single dose can treat and prevent flea infestations caused by Ctenocephalides spp., with effects lasting up to one month. This is due to the product's adult, larval, and ovicidal properties. Ovicidal activity persists for up to 3 weeks after administration. Monthly treatment of pregnant and lactating animals by reducing flea populations also helps prevent flea infestations in pups before 7 weeks of age. This product can be used as part of a flea allergy dermatitis treatment regimen; its ovicidal and larval-killing effects help control existing environmental flea infestations in areas accessible to the animal. Monthly administration can prevent canine heartworm disease caused by Dirofilaria immitis. Stronghold is safe for use in animals already infected with adult Dirofilaria immitis; however, according to good veterinary practice, it is recommended that all animals aged 6 months and older living in countries with vectors be tested for adult Dirofilaria immitis infection before initiating treatment with Stronghold. Even with monthly Stronghold administration, regular testing for adult canine heartworm infection in dogs is recommended as an important part of a canine heartworm prevention strategy. This product is ineffective against adult canine heartworm. It is used to treat ear mites (Otodectes cynotis). Cats: Treats feline flea (Felicola subrostratus) infection; treats adult feline toxocara cati infection; treats adult canine hookworm (Ancylostoma tubaeforme) infection. Dogs: Treats canine flea (Trichodectes canis) infection; treats sarcoptes scabies (caused by Sarcoptes scabiei); treats adult canine toxocara canis infection. |
| Molecular Formula |
C43H63NO11
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|---|---|
| Molecular Weight |
769.96000
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| Exact Mass |
769.44
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| CAS # |
220119-17-5
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| Related CAS # |
220119-17-5
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| PubChem CID |
9578507
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
917.0±65.0 °C at 760 mmHg
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| Flash Point |
508.4±34.3 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.618
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| LogP |
6.83
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
55
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| Complexity |
1550
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| Defined Atom Stereocenter Count |
14
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| SMILES |
C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7
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| InChi Key |
AFJYYKSVHJGXSN-XHKIUTQPSA-N
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| InChi Code |
InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1
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| Chemical Name |
(1R,4S,5'S,6R,6'S,8R,10E,12S,13S,14E,16E,20R,21Z,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~129.88 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.25 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (3.25 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (3.25 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2988 mL | 6.4938 mL | 12.9877 mL | |
| 5 mM | 0.2598 mL | 1.2988 mL | 2.5975 mL | |
| 10 mM | 0.1299 mL | 0.6494 mL | 1.2988 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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