Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
SCR-1481B1 (also known as c-Met inhibitor 2) is a novel potent and selective MET inhibitor. SCR-1481B1 inhibited MET kinase with IC50 value of 1.7 nM. It has potential anticancer activities. With an IC50 value of 1.7 nM, SCR-1481B1 inhibited MET kinase. It may possess anticancer properties. Strong substance SCR-1481B1 functions as a VEGFR inhibitor in addition to its activity against cancers that is reliant on Met activation. 3-amino is the chemical name. 2.-hydroxyethyl-3-pentane 1-(5,5-diol) (3-((4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)carbamoyl)-5-(4-fluorophenyl) 1-oxopyridin-1(4H)-yl)methyl phosphate.
Targets |
VEGFR1
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ln Vitro |
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ln Vivo |
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Enzyme Assay |
BMS-794833, the active component of BMS-817378, has an IC50 of 1.7 nM/15 nM, making it a strong ATP competitive inhibitor of Met/VEGFR2. It also has an IC50 of <3 nM for Ron, Axl, and Flt3.
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Animal Protocol |
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References |
Molecular Formula |
C31H35CLF2N5O10P
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Molecular Weight |
742.067
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Elemental Analysis |
C, 50.18; H, 4.75; Cl, 4.78; F, 5.12; N, 9.44; O, 21.56; P, 4.17
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CAS # |
1174161-86-4
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Related CAS # |
1174161-86-4 (tris);1174161-69-3;
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Appearance |
Solid powder
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SMILES |
C1=CC(=CC=C1C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)COP(=O)(O)O)F.C(C(CO)(CO)N)O
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InChi Key |
SDCKZXWUASKHNF-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C24H18ClF2N4O7P.C4H11NO3/c25-21-20(7-8-29-23(21)28)38-19-6-5-15(9-18(19)27)30-24(33)17-11-31(12-37-39(34,35)36)10-16(22(17)32)13-1-3-14(26)4-2-13;5-4(1-6,2-7)3-8/h1-11H,12H2,(H2,28,29)(H,30,33)(H2,34,35,36);6-8H,1-3,5H2
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Chemical Name |
[3-[[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxopyridin-1-yl]methyl dihydrogen phosphate;2-amino-2-(hydroxymethyl)propane-1,3-diol
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Synonyms |
BMS-817378; BMS 817378; BMS817378; SCR-1481B1; SCR 1481B1; SCR1481B1
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.04 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (3.04 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.3476 mL | 6.7379 mL | 13.4758 mL | |
5 mM | 0.2695 mL | 1.3476 mL | 2.6952 mL | |
10 mM | 0.1348 mL | 0.6738 mL | 1.3476 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.