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    Schisandrin B (γ-Schisandrin; Sch B)
    Schisandrin B (γ-Schisandrin; Sch B)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0232
    CAS #: 61281-37-6Purity ≥98%

    Description: Schisandrin B (γ-Schisandrin; Sch B) is a naturally occuring and the most abundant dibenzocyclooctadiene lignan isolated from traditional Chinese medicinal herb Schisandra chinensis (Turcz.) with antioxidant effect on rodent liver and heart. Baill. Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that α-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction.

    References: Mol Cell Biochem. 1996 Dec 20;165(2):161-5; PLoS One. 2015 Mar 5;10(3):e0119214.

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    Molecular Weight (MW)400.46
    FormulaC23H28O6
    CAS No.61281-37-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 80 mg/mL (199.8 mM)
    Water: <1 mg/mL
    Ethanol: 10 mg/mL (25.0 mM)
    SMILESC[[email protected]](C1)[[email protected]@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC
    SynonymsGamma-Schisandrin; Wuweizisu B; Wuweizisu-B; Schizandrin-B


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    In Vitro

    In vitro activity: Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance


    Cell Assay: Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. SB inhibited mitogen-induced proliferation and cytokine secretion by lymphocytes. Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells. Sch B exerted significant neuroprotective effects against microglial-mediated inflammatory injury in microglia-neuron co-cultures. Sch B significantly downregulated pro-inflammatory cytokines, including nitrite oxide (NO), tumor necrosis factor (TNF)-α, prostaglandin E(2) (PGE(2)), interleukin (IL)-1β and IL-6. Sch B could inhibit TGF-β induced EMT of 4T1 cells and of primary human breast cancer cells.

    In VivoSchisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion.
    Animal modelMice
    Formulation & DosageN/A
    References

    Free Radic Biol Med. 1996;21(5):709-12; Cell Stress Chaperones. 2001 Jan;6(1):44-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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