| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
SBI-0640756 (SBI-756) is an eIF4G1 inhibitor that is soluble in water. In parental and BRAFi-resistant melanomas, eIF4F complexes are disrupted by SBI-0640756 (SBI-756) (0-1 μM). SBI-0640756 (SBI-756) suppresses AKT, NF-κB, and AKT/mTORC1 activities in addition to having inhibitory effects on human melanoma lines [1].
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|---|---|
| ln Vivo |
SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) 50% decreased tumor incidence and delayed carcinogenesis in the NrasQ61K/Ink4a–/– genetic model. When used in conjunction with a BRAF inhibitor, SBI-0640756 (SBI-756) (1 mg/kg, twice weekly, i.p.) efficiently suppresses the growth of existing tumors without turning immunodeficient mice bearing A375 tumors back into normal. of tumor development [1].
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| References |
| Molecular Formula |
C23H14CLFN2O2
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|---|---|
| Molecular Weight |
404.820868015289
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| Exact Mass |
404.072
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| CAS # |
1821280-29-8
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| PubChem CID |
121241171
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
4.1
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
29
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| Complexity |
701
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1C=CC2=C(C=1)C(C1C=CC=CC=1)=C(C(C=CC1C=NC=C(C=1)F)=O)C(N2)=O
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| InChi Key |
VVWGPQZBDQVQRC-RMKNXTFCSA-N
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| InChi Code |
InChI=1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
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| Chemical Name |
6-chloro-3-[(E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
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| Synonyms |
SBI0640756; SBI 0640756; SBI-0640756
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 26 mg/mL (~64.23 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 5 mg/mL (12.35 mM) in 50% PEG300 + 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (6.18 mM) in 0.5% CMC-Na/saline water (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4702 mL | 12.3512 mL | 24.7023 mL | |
| 5 mM | 0.4940 mL | 2.4702 mL | 4.9405 mL | |
| 10 mM | 0.2470 mL | 1.2351 mL | 2.4702 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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