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    SAR-20347
    SAR-20347

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3369
    CAS #: 1450881-55-6; 1450881-50-6Purity ≥98%

    Description: SAR-20347 is a novel and potent small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2) over other JAK family members. In cellular assays, SAR-20347 dose dependently (1 nM-10 μM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors. In vivo, TYK2 mutant mice or treatment of wild-type mice with SAR-20347 significantly reduced IL-12-induced IFN-γ production and IL-22-dependent serum amyloid A to similar extents, indicating that, in these models, SAR-20347 is probably acting through inhibition of TYK2. In an imiquimod-induced psoriasis model, the administration of SAR-20347 led to a striking decrease in disease pathology, including reduced activation of keratinocytes and proinflammatory cytokine levels compared with both TYK2 mutant mice and wild-type controls. Taken together, these data indicate that targeting both JAK1- and TYK2-mediated cytokine signaling is more effective than TYK2 inhibition alone in reducing psoriasis pathogenesis.

    References:  2014 Oct 1;193(7):3278-87.  

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    SAR-20347

    Name: SAR-20347
    CAS#: 1450881-55-6
    Chemical Formula: C21H18ClFN4O4
    Exact Mass: 444.1001
    Molecular Weight: 444.8474
    Elemental Analysis: C, 56.70; H, 4.08; Cl, 7.97; F, 4.27; N, 12.59; O, 14.39
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: SAR-20347; SAR 20347; SAR20347
    Chemical Name: 2-(2-Chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide
    InChi Key: HEDPDFHTQKEORT-UHFFFAOYSA-N
    InChi Code: InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6-4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7,25H,8-11H2,(H2,24,28)
    SMILES Code: O=C(C1=C(NC2=CC=C(C(N3CCOCC3)=O)C=C2)OC(C4=C(F)C=CC=C4Cl)=N1)N


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    SAR20347 alters in vitro development of mouse T helper subsets.  2014 Oct 1;193(7):3278-87.

     SAR-20347


    SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.  2014 Oct 1;193(7):3278-87.

     SAR-20347


    SAR-20347 reduces imiquimod-induced inflammation and keratinocyte cell numbers.  2014 Oct 1;193(7):3278-87.

     SAR-20347


    SAR-20347 reduces imiquimod-induced inflammation and antimicrobial peptide production.  2014 Oct 1;193(7):3278-87.

     SAR-20347


    SAR-20347 treatment and TYK2 mutant mice show reduced IL-17 and Vγ3.  2014 Oct 1;193(7):3278-87.

     SAR-20347


    Proposed mechanism of action of SAR-20347 in ameliorating psoriasis-like symptoms.  2014 Oct 1;193(7):3278-87.


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