| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
At a dosage of 1 μg/mL, sarbeconazole exhibited full antifungal efficacy against all Aspergillus niger strains except one. Throughout the course of 14 days of testing, 80% of all strains (85% for Aspergillus fumigatus) showed no growth at all at a dose of 0.1 μg/mL [2].
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| ln Vivo |
Every control pigeon that had A infection. fumigatus passed away in two to five days. Their kidneys, liver, spleen, air sacs, and lungs all developed necrotic lesions. These organs have very positive histology and cultures. When given at 2.5 mg/kg, sarconazole proved ineffective; however, at 5 or 10 mg/kg, there was 100% or 92% survival and negative organ cultures, respectively. P igeons showed no signs of drug-related adverse effects [2].
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| References |
[1]. Otcenásek M, et al. Susceptibility of clinical isolates of fungi to saperconazole. Mycopathologia. 1992 Jun;118(3):179-83.
[2]. VVan Cutsem J, et al. Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals. Antimicrob Agents Chemother. 1989 Dec;33(12):2063-8 |
| Additional Infomation |
See also: Saperconazole (annotation moved to).
|
| Molecular Formula |
C35H38F2N8O4
|
|---|---|
| Molecular Weight |
672.73
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| Exact Mass |
672.298
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| CAS # |
110588-57-3
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| PubChem CID |
9809993
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.37g/cm3
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| Boiling Point |
812.5ºC at 760mmHg
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| Melting Point |
189.5°
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| Flash Point |
445.2ºC
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| Vapour Pressure |
1.81E-26mmHg at 25°C
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| Index of Refraction |
1.656
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| LogP |
4.678
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
49
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| Complexity |
1120
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1N(C(C)CC)N=CN1C2=CC=C(N3CCN(C4=CC=C(OCC5OC(CN6N=CN=C6)(C7=CC=C(F)C=C7F)OC5)C=C4)CC3)C=C2
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| InChi Key |
HUADITLKOCMHSB-ZPGVKDDISA-N
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| InChi Code |
InChI=1S/C35H38F2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
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| Chemical Name |
2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
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| Synonyms |
R66905; SPZ; Saperconazole
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~37.16 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4865 mL | 7.4324 mL | 14.8648 mL | |
| 5 mM | 0.2973 mL | 1.4865 mL | 2.9730 mL | |
| 10 mM | 0.1486 mL | 0.7432 mL | 1.4865 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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