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Description: Salubrinal is a novel, potent, cell-permeable and selective inhibitor of eIF2α (eukaryotic translation initiation factor 2 subunit α) dephosphorylation with potential anticancer activity. It inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in cell-free assays. The eukaryotic translation initiation factor 2 subunit α (eIF2α) is crucial in protein synthesis. eIF2α phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2α. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation.
References: Science, 2005, 307(5711), 935-939.; Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184.
Product Catalog 2022
Guide to Product Handling
InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N
InChi Code: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
SMILES Code: O=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS
NMR