| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Salicyl alcohol has multiple targets. It exhibits antiviral properties against HIV-1, HIV-2, and SARS-CoV-2. It serves as a precursor for salicin synthesis. It induces contact dermatitis and eczematous skin reactions, acting as a well-known allergen in phenolic resins.
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|---|---|
| ln Vitro |
In vitro, salicyl alcohol demonstrates antiviral activity with an EC50 value greater than 250,000 nM in CEM/O cells and inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 42.59% at 10 µM. It has antiseptic, antibacterial, and antipyretic activities.
|
| ln Vivo |
In vivo, salicyl alcohol induces contact dermatitis and eczematous skin reactions in sensitized individuals. It is used as a precursor for salicin synthesis in plants.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays for salicyl alcohol typically involve evaluating its antiviral activity using cell-based infection models. EC50 values are determined by measuring the inhibition of viral replication or cytopathic effect.
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| Cell Assay |
For in vitro cell-based assays, salicyl alcohol is dissolved in DMSO or aqueous buffers and applied to cultured cells such as Caco-2 or CEM/O cells at concentrations ranging from 1 µM to 1 mM. Effects on cell viability or viral replication are assessed after 24-72 hours of treatment.
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| Animal Protocol |
In vivo animal studies for salicyl alcohol are typically toxicological or sensitization studies. The compound is applied topically or administered orally at doses ranging from 1-100 mg/kg. Skin reactions and systemic effects are evaluated.
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| ADME/Pharmacokinetics |
Salicyl alcohol has a molecular weight of 124.14 g/mol. It is soluble in DMSO and serves as a highly efficient glucose acceptor in enzymatic transglucosylation reactions.
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| Toxicity/Toxicokinetics |
Salicyl alcohol is a strong sensitizer and induces contact dermatitis. It can cause eczematous skin reactions in sensitized individuals.
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| Additional Infomation |
Salicylol is a hydroxybenzyl alcohol, a compound of phenol in which a hydroxymethyl group is substituted at the C-2 position. It is a metabolic product of human urine. It is an aromatic primary alcohol and also a hydroxybenzyl alcohol. Its function is related to that of phenol and benzyl alcohol. Salicylol has been reported to be found in gardenia, European aspen, and several other organisms with relevant data.
Salicyl alcohol is used as a precursor for salicin synthesis and as a pharmaceutical intermediate. It is a well-known allergen identified in phenolic resins. It is also used in enzymatic transglucosylation reactions for the synthesis of salicin analogues. |
| Molecular Formula |
C7H8O2
|
|---|---|
| Molecular Weight |
124.1372
|
| Exact Mass |
124.052
|
| CAS # |
90-01-7
|
| Related CAS # |
27134-47-0
|
| PubChem CID |
5146
|
| Appearance |
Off-white to yellow solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
238.6±7.0 °C at 760 mmHg
|
| Melting Point |
83-85 °C(lit.)
|
| Flash Point |
115.2±12.8 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.596
|
| LogP |
0.3
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
9
|
| Complexity |
83
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
CQRYARSYNCAZFO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H8O2/c8-5-6-3-1-2-4-7(6)9/h1-4,8-9H,5H2
|
| Chemical Name |
2-(hydroxymethyl)phenol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~805.54 mM)
H2O : ~33.33 mg/mL (~268.49 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 110 mg/mL (886.10 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.0554 mL | 40.2771 mL | 80.5542 mL | |
| 5 mM | 1.6111 mL | 8.0554 mL | 16.1108 mL | |
| 10 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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