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    Sacubitrilat (LBQ-657)
    Sacubitrilat (LBQ-657)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4542
    CAS #: 149709-44-4Purity ≥98%

    Description: Sacubitrilat (also known as LBQ-657) is the activated form of Sacubitril hemicalcium (also known as AHU-377 hemicalcium) which is a novel and potent NEP (neutral endopeptidase 24.11) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril is a prodrug that can be activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

    References: J Med Chem. 1995 May 12;38(10):1689-700.Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.Circ Heart Fail. 2015 Jan;8(1):71-8.

    Related CAS : 149709-44-4 (Sacubitrilat); 1369773-39-6 (hemi-calcium); 149709-62-6 (free acid); 149690-05-1 (sodium); 936623-90-4 (mixture with valsartan); 936623-90-4; 137862-53-4; 

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    Sacubitrilat

    Name: Sacubitrilat
    CAS#: 149709-44-4
    Chemical Formula: C22H25NO5
    Exact Mass: 383.1733
    Molecular Weight: 383.444
    Elemental Analysis: C, 68.91; H, 6.57; N, 3.65; O, 20.86
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: LBQ-657; LBQ 657; LBQ657; Sacubitrilat.
    IUPAC/Chemical Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
    InChi Key: DOBNVUFHFMVMDB-BEFAXECRSA-N
    InChi Code: InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
    SMILES Code: O=C(O)[[email protected]](C)C[[email protected]](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1


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