| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 500mg |
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| 1g | |||
| Other Sizes |
| ADME/Pharmacokinetics |
Metabolism/Metabolites
Norenicotine is a known metabolite of nicotine in the human body. |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
...Norepinephrine causes abnormal protein glycosylation and catalyzes covalent modification of certain prescription drugs (e.g., the commonly used steroid prednisone). ... Non-human Toxicity Values Mouse intravenous LD50: 3409 μg/kg (3.409 mg/kg) Mouse intraperitoneal LD50: 14,660 μg/kg (14.66 mg/kg) Rabbit intravenous LD50: 3 mg/kg |
| Additional Infomation |
(S)-Nornicotinic acid is a pyridine alkaloid, a compound of nicotine pyrrolidine lacking a methyl group on the nitrogen atom. It is a metabolite, a nicotine acetylcholine receptor agonist, and a plant-derived insecticide. It is both a pyridine alkaloid and a pyrrolidine alkaloid. It is the conjugate base of (S)-nornicotinic acid (1+) and the enantiomer of (+)-nornicotinic acid. It is derived from the hydride of nicotine. 3-[(2S)-pyrrolidine-2-yl]pyridine has been reported in tobacco (Nicotiana suaveolens), tobacco (Nicotiana tomentosa), and other organisms with relevant data.
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| Molecular Formula |
C9H12N2
|
|---|---|
| Molecular Weight |
148.2050
|
| Exact Mass |
148.1
|
| CAS # |
494-97-3
|
| Related CAS # |
(S)-Nornicotine hydrochloride;101832-65-9
|
| PubChem CID |
91462
|
| Appearance |
Light yellow to brown liquid
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| Density |
1.043g/cm3
|
| Boiling Point |
269.999ºC at 760 mmHg
|
| Flash Point |
111.291ºC
|
| Vapour Pressure |
0.007mmHg at 25°C
|
| Index of Refraction |
1.536
|
| LogP |
1.834
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
11
|
| Complexity |
125
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
N1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])N=C([H])C([H])=C1[H]
|
| InChi Key |
MYKUKUCHPMASKF-VIFPVBQESA-N
|
| InChi Code |
InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/t9-/m0/s1
|
| Chemical Name |
3-[(2S)-pyrrolidin-2-yl]pyridine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~674.72 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.87 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.87 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.87 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7472 mL | 33.7359 mL | 67.4718 mL | |
| 5 mM | 1.3494 mL | 6.7472 mL | 13.4944 mL | |
| 10 mM | 0.6747 mL | 3.3736 mL | 6.7472 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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