| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Rosoxacin (0.03-8 µg/mL; 24 h) has good sensitivity to 32 species of Neisseria gonorrhoeae, with a MIC range of 0.03-0.125 µg/mL[1]. Rosoxacin (0.03-8 µg/mL; 48 h) has antibacterial activity against Chlamydia trachomatis (11 strains) with a MIC of 5 µg/mL [1]. Rosoxacin (0.03-8 µg/mL; 6 days) has antibacterial activity against Ureaplasma urealyticum (7 strains) with a MIC range of 2-8 µg/mL [1].
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| Cell Assay |
Cell viability assay [1]
Cell Types: Neisseria gonorrhoeae (32 strains) Tested Concentrations: 0.03-8 µg/mL Incubation Duration: 24 hrs (hours) Experimental Results: demonstrated good anti-gonococcal activity. Neisseria gonorrhoeae, 50% (32 strains) of the strains had an MIC of 0.03 µg/mL, and 90% of the strains had an MIC of 0.06 µg/mL. Cell viability determination [1] Cell Types: Chlamydia trachomatis (11 strains) Tested Concentrations: 0.03-8 µg/mL Incubation Duration: 48 h Experimental Results: 11 strains of Chlamydia trachomatis were inhibited, and the MIC was 5 µg/mL. Cell viability assay [1] Cell Types: Ureaplasma urealyticum (7 strains) Tested Concentrations: 0.03-8 µg/mL Incubation Duration: 6 days Experimental Results: Inhibited 7 strains of Ureaplasma urealyticum, MIC range was 2-8 µg/mL. |
| References |
[1]. Dobson RA, et al. In vitro antimicrobial activity of rosoxacin against Neisseria gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum. Antimicrob Agents Chemother. 1980 Nov;18(5):738-40.
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| Additional Infomation |
Rosoxacin is a quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has been used for treating urinary tract infections and certain sexually transmitted diseases. It has a role as an antibacterial drug and an antiinfective agent. It is a quinolone antibiotic, a quinolinemonocarboxylic acid and a member of pyridines.
Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock. Drug Indication For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Mechanism of Action Rosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Pharmacodynamics Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. |
| Molecular Formula |
C17H14N2O3
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|---|---|
| Molecular Weight |
294.3047
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| Exact Mass |
294.1
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| CAS # |
40034-42-2
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| PubChem CID |
287180
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.317g/cm3
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| Boiling Point |
500.8ºC at 760 mmHg
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| Melting Point |
290°
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| Flash Point |
256.7ºC
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| Index of Refraction |
1.633
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| LogP |
2.781
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
22
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| Complexity |
482
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1C(C(=O)O[H])=C([H])N(C([H])([H])C([H])([H])[H])C2C([H])=C(C3C([H])=C([H])N=C([H])C=3[H])C([H])=C([H])C=21
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| InChi Key |
XBPZXDSZHPDXQU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
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| Chemical Name |
1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~20.83 mg/mL (~70.78 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.07 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.07 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3979 mL | 16.9895 mL | 33.9789 mL | |
| 5 mM | 0.6796 mL | 3.3979 mL | 6.7958 mL | |
| 10 mM | 0.3398 mL | 1.6989 mL | 3.3979 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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