| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Following administration of radioactive tricene, the highest concentrations of tricene and its derivatives in all tissues were reached after 12 hours. …After 7 days of oral administration, the residual amounts of tricene and its oxygen analogues were similar. The tissue residual time, from longest to shortest, was: liver, kidney, spleen, subcutaneous and mesenteric fat, heart, and brain. Organophosphorus pesticides are absorbed through the gastrointestinal tract, skin, or lungs and distributed throughout the body. They do not accumulate in any specific tissue. /Organophosphorus pesticides/ ...Six pesticides (diazinon, dimethoate, dithiophos, ethion, parathion, and rhodolphos)...have been recovered from various extracts, including alfalfa, lettuce, milk, chicken, halibut, bees, and urine, at concentrations down to the nanogram level. ...Fluorochlorophosphorus is stored in body fat...It can be detected in milk after oral administration in cattle... Metabolisms/Metabolites Trimethylbenzene and its oxygen analogs are hydrolyzed in rats, initially excreted in urine as phenyl phosphate esters. Thiophosphate. These are reduced...while the excretion of dimethyl phosphate increases. ...At a dose of 100 mg/kg, 42% of Ronnel is metabolized to demethylRonnel, compared to only 6% at a dose of 2 mg/kg. /In urine after oral administration in rats/ Two major pathways of Ronnel metabolism of roughly equal importance have been established: hydrolysis of o-phenol bonds and hydrolysis of o-methyl bonds to form secondary esters... In vitro studies of rat brain and liver preparations have shown the formation of oxygen analogs of Ronnel, which is the source of Ronnel toxicity. For more complete data on the metabolisms/metabolites of Ronnel (6 metabolites in total), please visit the HSDB record page. |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
Ronnell has not been shown to significantly enhance the effects of any commonly used organophosphate insecticides. Non-human Toxicity Values Male Rat Oral LD50: 1250 mg/kg Female Rat Oral LD50: 2630 mg/kg Dog Oral LD50: >500 mg/kg Rat Dermal LD50: 2000 mg/kg Rabbit Dermal Absorption LD50: 1000-2000 mg/kg |
| References | |
| Additional Infomation |
Ronnel is a white to light brown crystalline solid. Melting point: 41°C, density: 1.49 g cm⁻³ at 25°C. It is a cholinesterase inhibitor with bactericidal activity (toxic to varying degrees in all animals). Used as an insecticide. It is readily degraded in the environment through hydrolysis and oxidative degradation.
Benzyl chlorophos is an organothiophosphate. Ronnel is a synthetic organothiophosphate compound and also an organophosphate acetylcholinesterase inhibitor, used as an insecticide. It is a colorless or white to light brown crystalline solid with a thiol odor and can enter the human body through inhalation, ingestion, or contact. Mechanism of Action Most organophosphate pesticides are not effective esterase inhibitors before being activated by microsomal oxidases in the liver. Organophosphate pesticides Ronnel is a weak inhibitor of cholinesterase. It primarily affects pseudoesterases in plasma, rather than true acetylcholinesterase in erythrocytes, regardless of whether it is a single or repeated oral administration. Therapeutic Uses Ronnell was the first systemic insecticide for animals and remains effective for oral and contact administration to livestock. Veterinary Drug: Fluroxypyr is a systemic insecticide…for oral administration to cattle to control ectoparasites. Veterinary Drug:…for the treatment of bovine psoriasis. Veterinary Drug: Limited studies suggest it may be effective against Halbroni's disease in horses. For more complete data on the therapeutic uses of Ronnell (10 in total), please visit the HSDB records page. Drug Warnings Veterinarian: Do not use on lactating dairy cows; discontinue use 10 days before calving; do not use on animals exposed to cholinesterase inhibitors. |
| Molecular Formula |
C8H8CL3O3PS
|
|---|---|
| Molecular Weight |
321.53
|
| Exact Mass |
319.899
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| CAS # |
299-84-3
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| PubChem CID |
9298
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
|
| Boiling Point |
344.7±52.0 °C at 760 mmHg
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| Melting Point |
35ºC
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| Flash Point |
162.3±30.7 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
|
| Index of Refraction |
1.578
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| LogP |
4.84
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
16
|
| Complexity |
273
|
| Defined Atom Stereocenter Count |
0
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| InChi Key |
JHJOOSLFWRRSGU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3
|
| Chemical Name |
dimethoxy-sulfanylidene-(2,4,5-trichlorophenoxy)-λ5-phosphane
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| Synonyms |
Ectoral; Dermafosu; Ronnel
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~310.99 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1101 mL | 15.5506 mL | 31.1013 mL | |
| 5 mM | 0.6220 mL | 3.1101 mL | 6.2203 mL | |
| 10 mM | 0.3110 mL | 1.5551 mL | 3.1101 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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