| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
AFTER ADMIN OF RADIOACTIVE TROLENE, HIGHEST LEVELS OF TROLENE & ITS DERIVATIVES IN ALL TISSUES WERE REACHED AFTER 12 HR. ... RESIDUES PERSISTING 7 DAYS AFTER ORAL ADMIN WERE SIMILAR FOR TROLENE & ITS OXYGEN ANALOG. TISSUES IN ORDER OF DECR PERSISTENCE ... /WERE/ LIVER, KIDNEY, SPLEEN, SUBCUTANEOUS & MESENTERIC FAT, HEART, BRAIN. FOLLOWING ABSORPTION FROM GI TRACT, SKIN, OR LUNGS, ORGANOPHOSPHATE PESTICIDES ARE DISTRIBUTED THROUGHOUT BODY. THEY DO NOT ACCUM IN ANY PARTICULAR TISSUE. /ORGANOPHOSPHATE PESTICIDES/ ... SIX PESTICIDES (DIAZINON, DIMETHOATE, DISULFOTON, ETHION, PARATHION, & RONNEL) ... /HAVE BEEN RECOVERED/ IN LOW NANOGRAM RANGE FROM SUCH DIVERSE EXTRACTS AS ALFALFA, LETTUCE, MILK ... CHICKENS, HALIBUT, BEES, & URINE. ... FENCHLORPHOS IS STORED IN BODY FAT ... IT IS FOUND IN MILK AFTER ORAL DOSING ... /OF CATTLE/. Metabolism / Metabolites TROLENE & ITS OXYGEN ANALOG WERE HYDROLYZED IN RATS & EXCRETED IN URINE INITIALLY AS PHENYL PHOSPHORIC & PHOSPHOROTHIOIC ACIDS. THESE DECR ... WHILE EXCRETION OF DIMETHYL PHOSPHORIC ACID INCR. ... 42% OF RONNEL AT 100 MG/KG DOSAGE WAS METABOLIZED TO DESMETHYL RONNEL COMPARED TO 6% AT 2 MG/KG DOSAGE. /IN URINE OF RATS AFTER ORAL ADMIN/ TWO PRIMARY PATHWAYS OF APPROX EQUAL IMPORTANCE FOR RONNEL METABOLISM WERE DEMONSTRATED, HYDROLYSIS OF P-O-PHENOL BOND & HYDROLYSIS OF P-O-METHYL BOND TO SECONDARY ESTERS ... . In vitro studies with preparations from rat brain and liver, indicated the formation of the oxygen analog of ronnel and that this was the source of ronnel toxicity. For more Metabolism/Metabolites (Complete) data for RONNEL (6 total), please visit the HSDB record page. |
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| Toxicity/Toxicokinetics |
Interactions
Ronnel has not been shown to potentiate the effect of any of the commonly used organophosphorus insecticides to any significant extent. Non-Human Toxicity Values LD50 Rat (male) oral 1250 mg/kg LD50 Rat (female) oral 2630 mg/kg LD50 Dog oral >500 mg/kg LD50 Rat dermal 2000 mg/kg LD50 Rabbit skin absorption 1000-2000 mg/kg |
| References | |
| Additional Infomation |
Ronnel is a white to light-tan crystalline solid. Mp: 41 °C, Density :1.49 g cm-3 at 25 °C. Biocidal (toxic to all animal life in differing degrees) by its action as a cholinesterase inhibitor. Used as an insecticide. Degrades readily in the environment by hydrolysis and oxidation.
Fenchlorphos is an organic thiophosphate. Ronnel is a synthetic organic thiophosphate compound and organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a colorless or white to light tan crystalline solid with a mercaptan odor, and exposure occurs by inhalation, ingestion, or contact. Mechanism of Action MOST ... /ORGANOPHOSPHATE PESTICIDES/ ARE NOT POTENT INHIBITORS OF ESTERASES UNTIL THEY ARE ACTIVATED IN LIVER ... BY MICROSOMAL OXIDATIVE ENZYMES. /ORGANOPHOSPHORUS PESTICIDES/ Ronnel is a weak inhibitor of cholinesterase. It affects the pseudoesterase of the plasma predominantly, rather than the true acetylcholinesterase of the red blood cells, upon both single and repeated oral doses. Therapeutic Uses Ronnel was the first animal systemic insecticide and continues to be effectively used in livestock in oral and contact applications. MEDICATION (VET): FENCHLORPHOS IS A SYSTEMIC INSECTICIDE ... FOR ORAL ADMIN TO CATTLE AGAINST ECTOPARASITES. MEDICATION (VET): ... IN TREATMENT OF WARBLE INFESTATION IN CATTLE. MEDICATION (VET): LIMITED TRIALS INDICATE POSSIBLE USEFULNESS IN HABRONEMIASIS OF HORSES. For more Therapeutic Uses (Complete) data for RONNEL (10 total), please visit the HSDB record page. Drug Warnings VET: DO NOT USE IN LACTATING DAIRY CATTLE; WITHDRAW 10 DAYS PRIOR TO CALVING; DO NOT USE IN ANIMALS EXPOSED TO CHOLINESTERASE INHIBITORS. |
| Molecular Formula |
C8H8CL3O3PS
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|---|---|
| Molecular Weight |
321.53
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| Exact Mass |
319.899
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| CAS # |
299-84-3
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| PubChem CID |
9298
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
344.7±52.0 °C at 760 mmHg
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| Melting Point |
35ºC
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| Flash Point |
162.3±30.7 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.578
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| LogP |
4.84
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
16
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| Complexity |
273
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
JHJOOSLFWRRSGU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3
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| Chemical Name |
dimethoxy-sulfanylidene-(2,4,5-trichlorophenoxy)-λ5-phosphane
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| Synonyms |
Ectoral; Dermafosu; Ronnel
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~310.99 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1101 mL | 15.5506 mL | 31.1013 mL | |
| 5 mM | 0.6220 mL | 3.1101 mL | 6.2203 mL | |
| 10 mM | 0.3110 mL | 1.5551 mL | 3.1101 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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