| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
RO-10-5824 demonstrates 250-fold selectivity relative to human D3R receptors, high affinity binding with Ki=5.2±0.9 nM (n=3), and selectivity for D4 similar to human D2, D1, and D5 receptors. in contrast to over 1000 times. With an EC50 value of 205±67 nM (n=7) and a maximal induction of 36±4% above basal levels, RO-10-5824 promotes 35S-GTPγS binding [2].
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|---|---|
| ln Vivo |
Ro 10-5824 (3 mg/kg) increases the likelihood that ORD missions will succeed. At dosages of 1 and 3 mg/kg, Ro 10-5824 enhanced baseline gamma band activity in the frontal brain. On spontaneous motions, Ro 10-5824 had no effect [1]. In preliminary trials with C57 mice, RO-10-5824 (10.0 mg/kg) did not improve total turnover or central entrance in a single 60-minute open field in the absence of novel objects [2].
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| References |
[1]. Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl). 2015 Sep;232(17):3287-95.
[2]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81 |
| Molecular Formula |
C17H22CL2N4
|
|---|---|
| Molecular Weight |
353.289381504059
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| Exact Mass |
352.122
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| CAS # |
189744-94-3
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| PubChem CID |
16759174
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| Appearance |
Typically exists as solid at room temperature
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
|
| Heavy Atom Count |
23
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| Complexity |
362
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| Defined Atom Stereocenter Count |
0
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| SMILES |
NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2.[H]Cl.[H]Cl
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| InChi Key |
UZHMRJRDYCRKIZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H20N4.2ClH/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14;;/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20);2*1H
|
| Chemical Name |
2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;dihydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~283.05 mM)
DMSO : ~8.33 mg/mL (~23.58 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (141.53 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8305 mL | 14.1527 mL | 28.3054 mL | |
| 5 mM | 0.5661 mL | 2.8305 mL | 5.6611 mL | |
| 10 mM | 0.2831 mL | 1.4153 mL | 2.8305 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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