| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
With an IC50 value of roughly 100–200 μM, RN-1 dihydrochloride is cytotoxic to ovarian cancer cells (SKOV3, OVCAR3, A2780, and cisplatin inhibitor A2780cis) [3].
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| ln Vivo |
RN-1 dihydrochloride (3–10 mg/kg; i.p.; daily; for 2 or 4 weeks) effectively induces fetal hemoglobin (HbF) levels in red blood cells and decreases disease pathology in SCD [2]. In /6 rats, concentrations in the brain/arterial exposure ratio was 88.9 after 24 hours of intraperitoneal administration of RN-1 dihydrochloride (10 mg/kg).
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| Animal Protocol |
Animal/Disease Models: Sickle cell disease (SCD) mice [2]
Doses: 3mg/kg or 10mg/kg Route of Administration: ip; 1 dihydrochloride Dramatically impairs long-term memory, but not short-term memory [1 ]. Routine; 2 or 4 consecutive weeks Experimental Results: Effectively induced HbF levels in red blood cells and diminished disease pathology in SCD mice. |
| References |
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| Exact Mass |
451.179
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|---|---|
| CAS # |
1781835-13-9
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| PubChem CID |
129626553
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
30
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| Complexity |
492
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| Defined Atom Stereocenter Count |
2
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| SMILES |
Cl.Cl.O=C(CNC1CC1C1C=CC(=CC=1)OCC1C=CC=CC=1)N1CCN(C)CC1
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| InChi Key |
WMHAFZOOUBPQRX-VSIGASKDSA-N
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| InChi Code |
InChI=1S/C23H29N3O2.2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18/h2-10,21-22,24H,11-17H2,1H32*1H/t21-,22+/m0../s1
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| Chemical Name |
2-(((trans)-2-(4-(Benzyloxy)phenyl)cyclopropyl)amino)-1-(4-methylpiperazin-1-yl)ethanone Dihydrochloride
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| Synonyms |
RN1 RN 1 RN-1 Dihydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~20 mg/mL (~44.21 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 20 mg/mL (44.21 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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