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    Riluzole (RP-54274, PK 26124)
    Riluzole (RP-54274, PK 26124)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1078
    CAS #: 1744-22-5Purity ≥98%

    Description: Riluzole (formerly PK26124, RP54274, RP-54274, PK-26124; Rilutek), an anticonvulsant of the Na+ channel blocker class, is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic activities. Riluzole has been approved as a medication to treat amyotrophic lateral sclerosis. Riluzole acts by complex mechanism involving inhibition of voltage-dependent Na channels, high-voltage activated Ca and K channels, and inhibition of protein kinase C. It was suggested that this mechanism was involved in antioxidative processes.

    References: Neurology. 1996 Dec;47(6 Suppl 4):S233-41; Naunyn-Schmiedeberg's Archives of Pharmacology

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    Molecular Weight (MW)234.2
    FormulaC8H5F3N2OS
    CAS No.1744-22-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 47 mg/mL (200.7 mM)
    Water: <1 mg/mL
    Ethanol: 47 mg/mL (200.7 mM)
    Other info

    Chemical Name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

    InChi Key: FTALBRSUTCGOEG-UHFFFAOYSA-N

    InChi Code: InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

    SMILES: NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

    SynonymsPK 26124, RP 54274, PK26124, RP54274, RP-54274, PK-26124; Rilutek


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    In Vitro

    In vitro activity:  Riluzole inhibits the release of glutamic acid from cultured neurons, and from brain slices. These effects may be partly due to inactivation of voltage-dependent sodium channels on glutamatergic nerve terminals, as well as activation of a G-protein-dependent signal transduction process. Electrophysiologic experiments performed on isolated excitatory amino acid receptors expressed in the Xenopus oocyte have revealed that Riluzole inhibits currents evoked by N-methyl-D-aspartate (NMDA) (IC50 = 18 μM) and kainic acid (IC50 = 167 μM). Riluzole has been shown to stabilize inactivated sodium channels in frog sciatic nerve, in rat cerebellar granule cells, and on recombinant rat sodium channels expressed in Xenopus oocytes (Ki = 0.2 μM). Riluzole also blocks some of the postsynaptic effects of glutamic acid by noncompetitive blockade of NMDA receptors. Tiluzole protects cultured neurons from anoxic damage, from the toxic effects of glutamic-acid-uptake inhibitors, and from the toxic factor in the CSF of patients with amyotrophic lateral sclerosis.


    Cell Assay: In HEKGLT1, HEKGLAST or HEKEAAC1 cells, riluzole increased Na+-dependent uptake in a dose-dependent manner, with significant effects at concentrations as low as 0.01–0.1 μM and the highest effect at 100 μM. The increase in glutamate uptake induced by 100 μM riluzole was similar in all cell lines (+27% in HEKGLAST, +38% in HEKGLT1, +39% in HEKEAAC1). Higher riluzole concentrations (300 and 1000 μM) were toxic, since at the end of experiments the majority of cells were floating, and specific and non-specific glutamate uptake were reduced by more than 50%.

    In VivoRiluzole can easily cross the blood-brain barrier. Riluzole has neuroprotective, anticonvulsant, and sedative properties in vivo. In a rodent model of transient global cerebral ischemia, a complete suppression of the ischemia-evoked surge in glutamic acid release has been observed by Riluzole treatment (8 mg/kg i.p.).
    Animal modelRodent model of transient global cerebral ischemia
    Formulation & Dosage8 mg/kg i.p.
    References

    Neurology. 1996 Dec;47(6 Suppl 4):S233-41; Naunyn-Schmiedeberg's Archives of Pharmacology


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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