| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Targets |
Ribose does not have a specific biological target. It is a naturally occurring sugar that is fundamental to life, serving as a building block for nucleotides, RNA, and ATP. It is used by all living cells as a very basic source of metabolism. Its role in energy production is through its incorporation into ATP and other nucleotides.
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|---|---|
| ln Vitro |
As the sugar base of ATP, D-ribose (a combination of isomers) is a frequently utilized energy enhancer and metabolic processing supplement for cardiac energy metabolism or chronic fatigue syndrome [1]. In a RAGE-dependent manner, D-ribose (a combination of isomers) stimulates NF-κB inflammation and is active in protein glycation [1].
Ribose is not evaluated for direct pharmacological activity in cell-based assays. Its primary role in vitro is as a nutrient and metabolic substrate. It is used in cell culture media as an energy source and as a precursor for nucleotide synthesis. Its effects are assessed by measuring cellular ATP levels, nucleotide synthesis, and metabolic flux. It is also used as a reference standard in analytical chemistry. |
| ln Vivo |
Ribose is used as a nutritional supplement to support energy production, particularly in muscles and heart tissue. It has been studied for its potential benefits in improving athletic performance, reducing muscle fatigue, and supporting cardiovascular health. As a naturally occurring sugar, it is well-tolerated and has a long history of use as a dietary supplement.
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| Enzyme Assay |
Ribose does not have established receptor binding or enzyme inhibition assay protocols as it is a nutrient rather than a drug. Its identity and purity are confirmed by standard analytical methods including HPLC and polarimetry. Physical properties: molecular weight 150.13 g/mol; molecular formula C5H10O5; melting point: 88-92°C; specific rotation (α 20/D; 2%; water): -21.0 to -18.5°; water content: ≤0.5%; appearance: white crystalline powder.
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| Cell Assay |
Cellular studies with Ribose focus on its role in metabolism and energy production. Cells are cultured in media containing Ribose at various concentrations. ATP levels are measured using luciferase-based assays. Nucleotide synthesis is assessed by tracing labeled precursors. Cell viability and proliferation are assessed using standard assays. Ribose is also used as a control compound in metabolic studies.
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| Animal Protocol |
In vivo studies with Ribose are conducted as part of nutritional supplementation research. Animal models are used to evaluate its effects on exercise performance, muscle function, and cardiovascular health. The compound is administered orally at doses corresponding to human supplementation levels. Parameters assessed include ATP levels in muscle tissue, exercise endurance, and cardiac function. Sample sizes typically range from 8-12 animals per group. Clinical studies have been conducted for athletic performance and cardiovascular support.
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| ADME/Pharmacokinetics |
Ribose has a molecular weight of 150.13 g/mol and a molecular formula of C5H10O5. Melting point: 88-92°C. Specific rotation (α 20/D; 2%; water): -21.0 to -18.5°. Water content: ≤0.5%. Solubility: highly soluble in water. Storage: typically at room temperature, protected from moisture. As a dietary supplement, it is orally administered and absorbed from the gastrointestinal tract.
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| Toxicity/Toxicokinetics |
Ribose is generally recognized as safe (GRAS) for use as a food ingredient and dietary supplement. It is well-tolerated at recommended doses. Common adverse effects are rare and may include mild gastrointestinal upset at high doses. As a naturally occurring sugar, it has a very favorable safety profile. No significant toxicity has been identified at supplementation levels.
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| References | |
| Additional Infomation |
Aldehyde-D-ribose is a D-ribose, and also an aldehyde-ribose. It is the enantiomer of aldehyde-L-ribose. (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal has been reported in Streptomyces sporangiiformans, Arabidopsis thaliana, and other organisms with relevant data. It is a pentose that is active in biological systems and is usually present in its D-form. See also: D-ribose (note moved here).
Ribose is also known as D-Ribose and D-(-)-Ribose. Its IUPAC name is (2R,3R,4R)-2,3,4,5-tetrahydroxypentanal. It is a five-carbon sugar with strong water solubility and sweet taste. It is an essential component in living organisms for energy production. It is used as a nutritional supplement and in biochemical research. No regulatory approvals as a drug have been reported; it is marketed as a dietary supplement. |
| Molecular Formula |
C5H10O5
|
|---|---|
| Molecular Weight |
150.1299
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| Exact Mass |
150.052
|
| CAS # |
50-69-1
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| PubChem CID |
5311110
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
415.5±38.0 °C at 760 mmHg
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| Melting Point |
88-92ºC
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| Flash Point |
219.2±23.3 °C
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| Vapour Pressure |
0.0±2.2 mmHg at 25°C
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| Index of Refraction |
1.544
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| LogP |
-2.39
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
10
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| Complexity |
104
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| Defined Atom Stereocenter Count |
3
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| SMILES |
C([C@H]([C@H]([C@H](C=O)O)O)O)O
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| InChi Key |
PYMYPHUHKUWMLA-LMVFSUKVSA-N
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| InChi Code |
InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1
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| Chemical Name |
(2R,3R,4R)-2,3,4,5-tetrahydroxypentanal
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~666.09 mM)
DMSO : ≥ 100 mg/mL (~666.09 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (666.09 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6609 mL | 33.3045 mL | 66.6089 mL | |
| 5 mM | 1.3322 mL | 6.6609 mL | 13.3218 mL | |
| 10 mM | 0.6661 mL | 3.3304 mL | 6.6609 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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