| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
|
||
| 25g |
|
||
| 50g | |||
| 100g | |||
| 200g | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Riboflavin Sodium Phosphate is a coenzyme that is tightly bound to enzymes catalyzing substrate oxidations and reductions. It is a ribitol phosphate and a vitamin B2. It also acts as a photoinitiator.
|
|---|---|
| ln Vitro |
It is evident that riboflavine phosphate sodium is a very effective NAD+-recycling agent because it regularly achieves high levels of NAP turnover together with good yields of the cyclohexanone product[3].
In vitro, Riboflavin Sodium Phosphate acts as an essential cofactor for a wide variety of biosynthetic transformations. It is used in research to study redox reactions and as a photoinitiator in polymerization. |
| ln Vivo |
In vivo, Riboflavin Sodium Phosphate is a bioactive form of riboflavin used by the body for cellular respiration. Deficiency leads to stomatitis and migraine.
|
| Enzyme Assay |
The activity of riboflavin phosphate as a coenzyme is assessed in enzyme assays. For example, it is used as a cofactor for enzymes like glutathione reductase. The enzyme activity is measured spectrophotometrically by monitoring the consumption of NADPH in the presence of the substrate.
|
| Cell Assay |
Cellular assays for Riboflavin Sodium Phosphate involve culturing cells in media deficient in riboflavin. The compound is added back to the media, and its ability to restore normal cellular function and proliferation is assessed.
|
| Animal Protocol |
In vivo, Riboflavin Sodium Phosphate is administered orally as a dietary supplement. It is also used in ophthalmic solutions for corneal cross-linking.
|
| ADME/Pharmacokinetics |
Riboflavin Sodium Phosphate has a molecular weight of 478.3 g/mol and a molecular formula of C17H20N4NaO9P. It is highly water-soluble. It is stable as a solid but may degrade in solution upon exposure to light.
|
| Toxicity/Toxicokinetics |
Riboflavin Sodium Phosphate is generally recognized as safe (GRAS) as a dietary supplement. High doses may cause a harmless yellow discoloration of urine.
|
| References |
|
| Additional Infomation |
Riboflavin sodium phosphate is a ribitol phosphate ester belonging to vitamin B2. It is functionally related to riboflavin. It is a coenzyme for many oxidases, including NADH dehydrogenase. It is the main form of riboflavin found in cells and tissues. See also: Anhydrous riboflavin 5'-phosphate sodium (note moved to).
Riboflavin Sodium Phosphate is a widely available vitamin supplement. It is also used in biomedical research as a photoinitiator and for corneal cross-linking in ophthalmology. |
| Molecular Formula |
C17H20N4NAO9P
|
|---|---|
| Molecular Weight |
478.32
|
| Exact Mass |
478.086
|
| CAS # |
130-40-5
|
| Related CAS # |
146-17-8 (Parent);146-17-8 (Parent)
|
| PubChem CID |
23666409
|
| Appearance |
Light yellow to orange solid powder
|
| Melting Point |
>300°C
|
| Index of Refraction |
41 ° (C=1.5, 5mol/L HCl)
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
10
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
32
|
| Complexity |
856
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](COP(=O)(O)[O-])O)O)O.[Na+]
|
| InChi Key |
OHSHFZJLPYLRIP-BMZHGHOISA-M
|
| InChi Code |
InChI=1S/C17H21N4O9P.Na/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);/q;+1/p-1/t11-,12+,14-;/m0./s1
|
| Chemical Name |
sodium;[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
|
| Synonyms |
Flavin mononucleotide Hyryl Riboflavin Sodium Phosphate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~20.83 mg/mL (~43.55 mM)
DMSO : ~1 mg/mL (~2.09 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 4.17 mg/mL (8.72 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0907 mL | 10.4533 mL | 20.9065 mL | |
| 5 mM | 0.4181 mL | 2.0907 mL | 4.1813 mL | |
| 10 mM | 0.2091 mL | 1.0453 mL | 2.0907 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA