| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Reuterin does not have a specific receptor target. It is a broad-spectrum antimicrobial agent that acts through multiple mechanisms, primarily by reacting with thiol groups in proteins and enzymes. As a reactive aldehyde, it can disrupt cellular processes by alkylating essential biomolecules. Its activity is non-specific, affecting a wide range of microorganisms.
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|---|---|
| ln Vitro |
Reuterine has been investigated as a food preservative and supplementary medicinal agent since it is water soluble, effective across a broad pH range, and resistant to proteolytic and lipolytic enzymes. reuteri is a strong antibacterial agent that exhibits great efficacy against several isolates of Escherichia coli and Campylobacter jejuni [1]. Reuterin has broad-spectrum antibacterial activity against both enteric bacteria and pathogens and is produced by some strains of Lactobacillus reuteri during the anaerobic fermentation of glycerol [2].
In vitro, Reuterin has broad-spectrum antimicrobial activity. It is active against E. coli, several species of Bacteroides, Bifidobacterium, and Eubacterium with minimum inhibitory concentrations (MICs) ranging from 1.9 to 15 mM. It is also active against C. difficile and other pathogens. These values demonstrate its potent antimicrobial effects. |
| ln Vivo |
In vivo, Reuterin is produced by L. reuteri in the gastrointestinal tract and contributes to the antimicrobial activity of this probiotic bacterium. It is not administered as a therapeutic drug but is studied for its potential as a food preservative and antimicrobial agent.
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| Enzyme Assay |
A cell-free assay for Reuterin would involve measuring its antimicrobial activity by incubating it with bacterial cultures and determining the MIC. Its reactivity with thiol groups can be assessed using biochemical assays. Specific protocols are not detailed.
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| Cell Assay |
Cellular assays for Reuterin typically involve assessing its antimicrobial activity against bacterial cultures. Bacteria are incubated with varying concentrations of the compound, and the minimum inhibitory concentration (MIC) is determined. This is a standard method for evaluating the potency of antimicrobial agents.
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| Animal Protocol |
In vivo animal experiments for Reuterin are not described in the available sources. As a compound produced by probiotic bacteria, its effects have been studied in animal models of infection and gut health. However, specific protocols and data are not provided.
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| ADME/Pharmacokinetics |
Reuterin is a small, reactive aldehyde (3-hydroxypropionaldehyde). Its pharmacokinetic properties are not relevant as it is not a therapeutic drug. It is produced locally by bacteria in the gut.
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| Toxicity/Toxicokinetics |
Toxicity data for Reuterin are not provided in the available sources. As a reactive aldehyde, it may have toxic effects at high concentrations, but it is generally considered safe at the concentrations produced by L. reuteri. It is not used as a therapeutic drug.
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| References |
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| Additional Infomation |
3-Hydroxypropionaldehyde is an aldehyde containing α-CH2 and belongs to the propionaldehyde class of compounds.
Reuterin (CAS: 2134-29-4) is a broad-spectrum antimicrobial agent produced by Lactobacillus reuteri during anaerobic glycerol metabolism. Its primary component is 3-hydroxypropionaldehyde (3-HPA). It is active against Gram-positive and Gram-negative bacteria, yeasts, moulds, and protozoa. It has MIC values of 1.9-15 mM against various bacteria. It is used in microbiology, food safety, and antimicrobial mechanism research. |
| Molecular Formula |
C3H6O2
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|---|---|
| Molecular Weight |
74.0785
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| Exact Mass |
74.036
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| CAS # |
2134-29-4
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| PubChem CID |
75049
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| Appearance |
Colorless to light yellow viscous liquid
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
168.2±23.0 °C at 760 mmHg
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| Flash Point |
61.8±15.2 °C
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| Vapour Pressure |
0.5±0.7 mmHg at 25°C
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| Index of Refraction |
1.400
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| LogP |
-1.11
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
5
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| Complexity |
26.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])=O
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| InChi Key |
AKXKFZDCRYJKTF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C3H6O2/c4-2-1-3-5/h2,5H,1,3H2
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| Chemical Name |
3-hydroxypropanal
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~3374.73 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (1349.89 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 13.4989 mL | 67.4946 mL | 134.9892 mL | |
| 5 mM | 2.6998 mL | 13.4989 mL | 26.9978 mL | |
| 10 mM | 1.3499 mL | 6.7495 mL | 13.4989 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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