| Size | Price | Stock | Qty |
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| 5g |
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| Other Sizes |
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| ln Vitro |
D-amino acid oxidase (DAAO) and serine racemase (SR) break down (R)-serine after it is synthesized from L-serine. D-Ser is supported as an endogenous co-agonist acting at the glycine regulatory site of the NMDAR NR1 subunit by the distribution of D-Ser and NMDAR as shown by chemical measurements and immunohistochemistry [3].
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|---|---|
| ln Vivo |
(R)-Serine (10 g/L; oral; over 8 weeks) reduces weight gain caused by a high-fat diet [4].
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| Animal Protocol |
Animal/Disease Models: 4weeks old male C57Bl/6 mice
Doses: 10g/L Route of Administration: Orally (drinking water supplemented with 10g/L D-serine); Results throughout 8 weeks: Weight gain was Dramatically diminished within the first week of supplementation , paralleled weight gain in HFD-fed mice, but did not catch up thereafter. |
| References | |
| Additional Infomation |
D-serine is the R-enantiomer of serine. It has a role as a NMDA receptor agonist, a human metabolite and an Escherichia coli metabolite. It is a D-alpha-amino acid and a serine. It is a conjugate base of a D-serinium. It is a conjugate acid of a D-serinate. It is an enantiomer of a L-serine. It is a tautomer of a D-serine zwitterion.
D-Serine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). D-serine has been reported in Homo sapiens with data available. D-Serine is a non-essential amino acid and dextro isomer of serine with antipsychotic activity. D-serine is a selective full agonist at the glycine site of N-methyl-D-aspartate (NMDA)-type glutamate receptor. Hypofunction of NMDA type of neurotransmission is believed to play a major role in pathophysiology of schizophrenia, therefore, administration of D-serine and subsequent activation of NMDA receptors may alleviate psychotic tendencies. |
| Molecular Formula |
C3H7NO3
|
|---|---|
| Molecular Weight |
105.09258
|
| Exact Mass |
105.042
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| CAS # |
312-84-5
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| Related CAS # |
D-Serine-d3;1414348-52-9
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| PubChem CID |
71077
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
394.8±32.0 °C at 760 mmHg
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| Melting Point |
220 °C
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| Flash Point |
192.6±25.1 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
|
| Index of Refraction |
1.519
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| LogP |
-1.58
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
72.6
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
C([C@H](C(=O)O)N)O
|
| InChi Key |
MTCFGRXMJLQNBG-UWTATZPHSA-N
|
| InChi Code |
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
|
| Chemical Name |
(2R)-2-amino-3-hydroxypropanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~475.78 mM)
Methanol :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (475.78 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.5157 mL | 47.5783 mL | 95.1565 mL | |
| 5 mM | 1.9031 mL | 9.5157 mL | 19.0313 mL | |
| 10 mM | 0.9516 mL | 4.7578 mL | 9.5157 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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