| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
(R)-(-)-α-Methylhistamine dihydrochloride is more than ten times more efficient as an H3 agonist than histamine (HA). It is more than 1,000 times more selective for H3 receptors than HA is. (R) -(-)-α-Methylhistamine dihydrochloride has a pKi of 4.8 and less than 3.5 for H1 and H2 receptors, respectively, indicating a very low affinity. The dihydrochloride of (R)-(-)-α-methylhistamine binds to the H4 receptor more than 200 times [1][2][3].
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| ln Vivo |
Restoration with (R)-(-)-α-methylhistamine dihydrochloride (RAMH; 10 mg/kg; i.p.; 60 minutes before training) reversed propofol-induced (25 mg/kg; i.p. injection; 30 min before training) (R)-(-)-α-methylhistamine dihydrochloride (6.3 mg/kg; ip) significantly reduced t-MH levels in the mouse brain, and these compounds No significant changes in HA levels
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| Animal Protocol |
Animal/Disease Models: Male SD (SD (Sprague-Dawley)) rats (10-12 weeks) [3]
Doses: 10 mg/kg Route of Administration: IP; [3]. Results 60 minutes before training: Reversal of propofol-induced memory retention. |
| References |
|
| Molecular Formula |
C6H11N3.2[HCL]
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|---|---|
| Molecular Weight |
198.09352
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| Exact Mass |
197.049
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| CAS # |
75614-89-0
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| PubChem CID |
11957567
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| Appearance |
White to off-white ointment
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| LogP |
2.776
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
11
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| Complexity |
84.4
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[C@H](CC1=CN=CN1)N.Cl.Cl
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| InChi Key |
IZHCNQFUWDFPCW-ZJIMSODOSA-N
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| InChi Code |
InChI=1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1
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| Chemical Name |
(2R)-1-(1H-imidazol-5-yl)propan-2-amine;dihydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1262.05 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.50 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.50 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0482 mL | 25.2411 mL | 50.4821 mL | |
| 5 mM | 1.0096 mL | 5.0482 mL | 10.0964 mL | |
| 10 mM | 0.5048 mL | 2.5241 mL | 5.0482 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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