| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| References | |
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| Additional Infomation |
Quercetin 3-O-α-L-[6'''-p-coumaroyl-β-D-glucopyranoyl-(1->2)-rhamnoside] is a quercetin O-glucoside with a structure in which quercetin is linked to an α-L-[6'''-p-coumaroyl-β-D-glucopyranoyl-(1->2)-rhamnoside] residue at the 3-position via a glycosidic bond. This compound, isolated from Ginkgo biloba leaves, possesses antioxidant activity. It is both a metabolite and an antioxidant. It is a quercetin O-glucoside, cinnamic acid ester, and disaccharide derivative. Functionally, it is related to trans-4-coumaric acid. Quercetin-3-O-(6'''-trans-p-coumaroyl-2''-glucoyl)rhamnoside has been reported in Ginkgo biloba leaves, and relevant data are available.
Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1-2)-α-L-rhamnopyranoside (referred to in the text as compound 9) was one of the nine ingredients screened as major antioxidants from Shuxuening Injection (SI) [1]. The on-line ABTS+-CE-DAD method successfully separated and identified this compound along with others including clitorin, rutin, isoquercitrin, and kaempferol derivatives [1]. The total amount of these nine antioxidants (including this compound) showed a high correlation with the total antioxidative activity of SI (R² = 0.9456), indicating that they can be used as combinatorial active markers to assess the quality of SI across different batches [1]. The content range of this compound in 20 batches of SI was determined to be 65.5 - 86.9 μg·mL⁻¹ [1]. |
| Molecular Formula |
C36H36O18
|
|---|---|
| Molecular Weight |
756.660252571106
|
| Exact Mass |
756.19
|
| CAS # |
143061-65-8
|
| PubChem CID |
10169367
|
| Appearance |
White to yellow solid
|
| Density |
1.7±0.1 g/cm3
|
| Boiling Point |
1092.2±65.0 °C at 760 mmHg
|
| Flash Point |
342.0±27.8 °C
|
| Vapour Pressure |
0.0±0.3 mmHg at 25°C
|
| Index of Refraction |
1.756
|
| Source |
Originated from plants: Ginkgoaceae Ginkgo biloba
|
| LogP |
4.37
|
| Hydrogen Bond Donor Count |
10
|
| Hydrogen Bond Acceptor Count |
18
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
54
|
| Complexity |
1370
|
| Defined Atom Stereocenter Count |
10
|
| SMILES |
O(C1C(C(C(C(COC(C=CC2C=CC(=CC=2)O)=O)O1)O)O)O)C1C(OC2C(C3C(=CC(=CC=3OC=2C2C=CC(=C(C=2)O)O)O)O)=O)OC(C)C(C1O)O
|
| InChi Key |
LSMKTLJKBSXMMR-WLKGHKDFSA-N
|
| InChi Code |
InChI=1S/C36H36O18/c1-14-26(43)30(47)34(54-35-31(48)29(46)27(44)23(52-35)13-49-24(42)9-4-15-2-6-17(37)7-3-15)36(50-14)53-33-28(45)25-21(41)11-18(38)12-22(25)51-32(33)16-5-8-19(39)20(40)10-16/h2-12,14,23,26-27,29-31,34-41,43-44,46-48H,13H2,1H3/b9-4+/t14-,23+,26-,27+,29-,30+,31+,34+,35-,36-/m0/s1
|
| Chemical Name |
[(2R,3S,4S,5R,6S)-6-[(2S,3R,4R,5R,6S)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-4,5-dihydroxy-6-methyloxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~50 mg/mL (~66.1 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (1.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (12.5 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (1.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (12.5 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3216 mL | 6.6080 mL | 13.2160 mL | |
| 5 mM | 0.2643 mL | 1.3216 mL | 2.6432 mL | |
| 10 mM | 0.1322 mL | 0.6608 mL | 1.3216 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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