| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
The specific binding of [3H]NMS with Kis of 339, 193, and 497 nM in the mouse bladder, submandibular gland, and heart, respectively, is inhibited by propiverine (10-3000 nM) [2].
|
|---|---|
| ln Vivo |
In rats, propivirine (0.5 mg/day; PO once daily for two weeks) dramatically raises plasma norepinephrine and epinephrine levels as well as UBP and LPP during passive intravesical pressure raising [1]. At an in vivo dose of 1 mg/kg, propivirine (0.01–1 mg/kg; intravenously) totally suppresses the sneeze reflex and lowers UBP [1].
|
| Animal Protocol |
Animal/Disease Models: Female adult SD (SD (Sprague-Dawley)) rat (250-270 g) [1]
Doses: 5 mg dissolved in distilled water (0.5 mL) Route of Administration: Orally, one time/day for 2 weeks Experimental Results: Urethral baseline pressure (UBP ) increases and leakage point pressure (LPP) is significant. Plasma epinephrine and norepinephrine levels are increased. No significant changes in body weight were observed. |
| References |
|
| Additional Infomation |
Propiverine hydrochloride is a diarylmethane.
|
| Molecular Formula |
C23H29NO3.HCL
|
|---|---|
| Molecular Weight |
417.974
|
| Exact Mass |
403.191
|
| CAS # |
54556-98-8
|
| Related CAS # |
Propiverine;60569-19-9;Propiverine-d7 hydrochloride
|
| PubChem CID |
441412
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
494.7ºC at 760 mmHg
|
| Melting Point |
213-216ºC
|
| Flash Point |
253ºC
|
| LogP |
4.734
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
28
|
| Complexity |
429
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
KFUJMHHNLGCTIJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H
|
| Chemical Name |
(1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate;hydrochloride
|
| Synonyms |
Propiverine hydrochloride NSC-172140, NSC172140, NSC 172140 Mictonorm
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~50 mg/mL (~123.78 mM)
DMSO : ~50 mg/mL (~123.78 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.19 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (247.56 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3925 mL | 11.9626 mL | 23.9252 mL | |
| 5 mM | 0.4785 mL | 2.3925 mL | 4.7850 mL | |
| 10 mM | 0.2393 mL | 1.1963 mL | 2.3925 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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