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    Progesterone
    Progesterone

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1737
    CAS #: 57-83-0Purity ≥98%

    Description: Progesterone (Pregn-4-ene-3,20-dione), an endogenous steroid hormone and a precursor for the biosynthesis of all other steroidal hormones, is involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone plays an important role in establishing uterine receptivity for embryo implantation. Cooperated with nuclear progesterone receptor, progesterone could damper the action(s) of E2 and BPA on Egr1 expression. When tested with mouse melanoma (B16F10) cells and human melanoma (BLM) cells, progesterone treatment could significantly inhibit mouse melanoma cell growth. 

    References: J Biol Chem. 1998;273(17):10696-701; Nature. 2010;465(7299):803-7; J Neurosci. 2007;27(48):13357-65.

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    Molecular Weight (MW)314.46 
    FormulaC21H30O2 
    CAS No.57-83-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 22 mg/mL (70 mM) 
    Water: <1 mg/mL
    Ethanol: 63 mg/mL (200.3 mM) 
    Other info

    Chemical Name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

    InChi Key: RJKFOVLPORLFTN-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3

    SMILES Code: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

    Synonyms

    Pregn-4-ene-3,20-dione; Hormoflaveine; Lutociclina; Agolutin; Crinone; Luteohormone; Utrogestan; Cyclogest 


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    In Vitro

    In vitro activity: Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax).

    In VivoProgesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. 
    Animal modelMice
    Formulation & Dosage
    References

    J Biol Chem. 1998 Apr 24;273(17):10696-701; Nature. 2010 Jun 10;465(7299):803-7; J Neurosci. 2007 Nov 28;27(48):13357-65. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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