| Size | Price | Stock | Qty |
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| 1g |
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| 5g |
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| Other Sizes |
| Targets |
(+)-Corey Lactone does not have a biological target; it is a chiral synthetic intermediate used in the synthesis of prostaglandins. Prostaglandins are a family of lipid compounds that act as signaling molecules and have various biological activities, including regulation of inflammation, smooth muscle contraction, and platelet aggregation. The (+)-Corey lactone is a key building block for constructing the prostaglandin backbone in the correct stereochemical configuration.
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| ln Vitro |
In vitro activity is not measured for (+)-Corey Lactone as it is a synthetic intermediate. Its utility is demonstrated through successful conversion to prostaglandin analogs. The compound's chemical reactivity and stability under various reaction conditions are characterized in vitro.
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| ln Vivo |
In vivo activity is not applicable to (+)-Corey Lactone. The compound is a chemical intermediate used in the synthesis of prostaglandins, which are pharmacologically active. The intermediate itself is not administered in vivo.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to (+)-Corey Lactone. Standard characterization includes NMR spectroscopy (¹H, ¹³C) to confirm structure, HPLC to assess purity, and polarimetry to confirm optical rotation. The compound is typically evaluated for its suitability as a chiral building block in prostaglandin synthesis.
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| Cell Assay |
In vitro cellular assays are not performed on (+)-Corey Lactone. The compound is used as a chemical reagent in organic synthesis rather than a biological test agent. Its primary evaluation involves chemical properties such as solubility in organic solvents and stability under storage conditions.
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| Animal Protocol |
In vivo animal studies are not conducted on (+)-Corey Lactone. The compound is a synthetic intermediate used in the chemical synthesis of prostaglandins. Animal efficacy and toxicity studies are performed on the final prostaglandin products.
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| ADME/Pharmacokinetics |
Pharmacokinetic studies are not performed on (+)-Corey Lactone. The compound is a chemical intermediate and not a drug candidate. Its physicochemical properties, such as melting point and optical rotation, are characterized for synthetic applications.
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| Toxicity/Toxicokinetics |
Toxicological studies are not conducted on (+)-Corey Lactone. The compound is handled as a chemical reagent with standard laboratory precautions. Its safety data sheet indicates it is for research use only.
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| Additional Infomation |
(+)-Corey Lactone (CAS 76704-05-7) is the optically active (+)-enantiomer of the Corey lactone, also known as (3aS,4R,5S,6aR)-(+)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one. It is a key chiral intermediate in the synthesis of prostaglandins. The compound has a melting point of 114–118 °C and an optical rotation of [α]²⁰D = 44 ± 1° (c = 2.3 in MeOH). This product is for research use only.
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| Molecular Formula |
C8H12O4
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|---|---|
| Molecular Weight |
172.1785
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| Exact Mass |
172.073
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| CAS # |
76704-05-7
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| PubChem CID |
11084331
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
406.6±25.0 °C at 760 mmHg
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| Melting Point |
117-119ºC
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| Flash Point |
172.9±16.7 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
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| Index of Refraction |
1.546
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| LogP |
-2.18
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
203
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O1C(C([H])([H])[C@]2([H])[C@@]1([H])C([H])([H])[C@@]([H])([C@@]2([H])C([H])([H])O[H])O[H])=O
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| InChi Key |
VYTZWRCSPHQSFX-ZTYPAOSTSA-N
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| InChi Code |
InChI=1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m0/s1
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| Chemical Name |
(3aS,4R,5S,6aR)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8079 mL | 29.0394 mL | 58.0788 mL | |
| 5 mM | 1.1616 mL | 5.8079 mL | 11.6158 mL | |
| 10 mM | 0.5808 mL | 2.9039 mL | 5.8079 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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