| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
||
| 1g |
|
| Targets |
This intermediate does not have a specific biological target. Its importance lies in its chiral scaffold, which can be incorporated into drug molecules that target enzymes or receptors. The intermediate itself is not biologically active.
|
|---|---|
| ln Vitro |
In vitro, this compound is used as a building block for peptide mimetics and other heterocyclic drugs. The carboxylic acid can be coupled with amines, the hydroxyl group can be functionalized, and the Boc group can be deprotected. It is valuable for synthesizing antiviral and anticancer agents.
|
| ln Vivo |
In vivo, it is not administered as a therapeutic agent.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable. Characterization includes chiral HPLC, NMR, and MS.
|
| Cell Assay |
In vitro cellular assays are not performed on this intermediate.
|
| Animal Protocol |
In vivo animal studies are not conducted.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data are not available.
|
| Toxicity/Toxicokinetics |
The compound is a laboratory chemical; handle with care. May cause irritation.
|
| Additional Infomation |
(2R,4S)‑N‑BOC‑4‑Hydroxypiperidine‑2‑carboxylic acid is a chiral research intermediate used in drug synthesis, particularly for protease inhibitors. It is not approved for clinical use.
|
| Exact Mass |
259.141
|
|---|---|
| CAS # |
321744-26-7
|
| PubChem CID |
2734504
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
352.1±42.0 °C at 760 mmHg
|
| Flash Point |
166.8±27.9 °C
|
| Vapour Pressure |
0.0±1.8 mmHg at 25°C
|
| Index of Refraction |
1.495
|
| LogP |
0.44
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
18
|
| Complexity |
323
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
CC(C)(C)OC(=O)N1CC[C@@H](C[C@@H]1C(=O)OC)O
|
| InChi Key |
RNMVWSAJMIKMDY-DTWKUNHWSA-N
|
| InChi Code |
InChI=1S/C12H21NO5/c1-12(2,3)18-11(16)13-6-5-8(14)7-9(13)10(15)17-4/h8-9,14H,5-7H2,1-4H3/t8-,9+/m0/s1
|
| Chemical Name |
1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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