| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Human mononuclear leukocytes in culture that are directly interacting with C3a(70–77) exhibit concentration-dependent suppression of the synthesis of LIF elicited by mitogens and the antigen SK-SD[1]. C3a(70–77) increases vascular permeability in human skin, stimulates contraction of guinea pig ileal tissue, and causes histamine release and degranulation of rat mast cells. Ileal smooth muscle is desensitized to C3a(70–77) but not to human C5a, a similar anaphylatoxin. Cross-desensitization suggests that C3a(70–77) interacts with cellular C3a binding sites in a particular way[2].
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| References |
[1]. Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.
[2]. Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63. |
| Molecular Formula |
C37H62F3N13O12
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|---|---|
| Molecular Weight |
937.96
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| Related CAS # |
C3a (70-77);63555-63-5
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| Solubility (In Vitro) |
H2O :~100 mg/mL (~106.61 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (106.61 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0661 mL | 5.3307 mL | 10.6614 mL | |
| 5 mM | 0.2132 mL | 1.0661 mL | 2.1323 mL | |
| 10 mM | 0.1066 mL | 0.5331 mL | 1.0661 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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