| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
SLC-1/GPR24, MCHR2[1]
Melanin Concentrating Hormone, salmon TFA acts as a ligand for the orphan G protein-coupled receptors SLC-1 (GPR24/MCHR1) and MCHR2, which are involved in feeding behavior and energy homeostasis. |
|---|---|
| ln Vitro |
Not available. As a neuropeptide ligand, it binds to MCH receptors to activate downstream signaling pathways, though specific in vitro functional potency data such as EC50 or IC50 values are not provided in the literature.
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| ln Vivo |
Not available. The peptide is known to regulate food intake, energy balance, and sleep in teleost fish models, but quantitative in vivo pharmacodynamic data for the salmon isoform are not reported.
|
| Enzyme Assay |
Not available. For related MCH receptor binding assays, typical protocols involve radioligand binding using membranes from cells expressing MCHR1 or MCHR2, incubation with labeled MCH, and measurement of bound radioactivity.
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| Cell Assay |
Not available. For MCH functional assays, typical protocols involve calcium flux measurements in cells expressing MCH receptors, where MCH binding induces intracellular calcium increase detected by fluorescent indicators.
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| Animal Protocol |
Not available. For in vivo studies of MCH, standard protocols involve intracerebroventricular (ICV) injection in rodent models followed by monitoring of food intake, body weight, and locomotor activity over 24-72 hours.
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| ADME/Pharmacokinetics |
Not available. As a peptide neuropeptide with TFA salt, its pharmacokinetic properties may include rapid proteolytic degradation in vivo and typical peptide half-life of minutes to hours depending on administration route.
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| Toxicity/Toxicokinetics |
Not available. Peptide TFA salts generally exhibit manageable toxicity in animal studies at pharmacologically relevant doses, but specific toxicological data for this compound are not reported.
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| References | |
| Additional Infomation |
Melanin Concentrating Hormone, salmon TFA is strictly a research tool for studying MCH receptor biology and energy metabolism. It has not entered clinical trials nor received regulatory approval for any therapeutic indication. This product is exclusively for laboratory use and not intended for human therapeutic administration.
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| Molecular Formula |
C91H140F3N27O26S4
|
|---|---|
| Molecular Weight |
2213.50
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| Related CAS # |
Melanin Concentrating Hormone, salmon;87218-84-6
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| Appearance |
Solid powder
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O :~25 mg/mL (~11.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (45.18 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.4518 mL | 2.2589 mL | 4.5177 mL | |
| 5 mM | 0.0904 mL | 0.4518 mL | 0.9035 mL | |
| 10 mM | 0.0452 mL | 0.2259 mL | 0.4518 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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