| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
MeO-AMVN or copper ions-induced LDL oxidation are inhibited by cinnamontannin A2 (0.125-2.0 μg/mL)[3].
|
|---|---|
| ln Vivo |
Through the regulation of the Nrf2-Keap1 pathway, cinnamontannin A2 (10 mg/kg; ip for 30 days) improves the levels of KIM1 and NAGL in 5/6 nephractomized rats[2]. Mice's plasma contains more insulin and glucagon-like peptide-1 (GLP-1) when cinnamontannin A2 (10 μg/kg; po) is added[1]. In mice, cinnamontannin A2 (10 μg/kg; po) dramatically increases the phosphorylation of IRS-1 and IRB[1].
|
| Animal Protocol |
Animal/Disease Models: Male SD (Sprague-Dawley) rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys[2]
Doses: 10 mg/kg Route of Administration: Ip for 30 days Experimental Results: Ameliorated the altered level of creatinine, blood urea nitrogen , Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea. decreased the oxidative stress level. Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue. decreased the tubular injury score in the kidney tissue. |
| References |
|
| Additional Infomation |
Cinnamomum tannin A2 is a proanthocyanidin isolated from cinnamon (Cinnamomum cassia). It is a plant metabolite. Cinnamomum tannin A2 has been reported to exist in cinnamon (Cinnamomum iners), hawthorn (Crataegus pinnatifida), and other organisms with relevant data.
|
| Molecular Formula |
C60H50O24
|
|---|---|
| Molecular Weight |
1155.02
|
| Exact Mass |
1154.269
|
| CAS # |
86631-38-1
|
| PubChem CID |
16130899
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.8±0.1 g/cm3
|
| Index of Refraction |
1.839
|
| Source |
Originated from plants: Lauraceae Cinnamomum cassia (L.) D. Don
|
| LogP |
-0.07
|
| Hydrogen Bond Donor Count |
20
|
| Hydrogen Bond Acceptor Count |
24
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
84
|
| Complexity |
2210
|
| Defined Atom Stereocenter Count |
11
|
| SMILES |
C1[C@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=C3C(=CC(=C4[C@@H]5[C@H]([C@H](OC6=C(C(=CC(=C56)O)O)[C@@H]7[C@H]([C@H](OC8=CC(=CC(=C78)O)O)C9=CC(=C(C=C9)O)O)O)C1=CC(=C(C=C1)O)O)O)O)O)C1=CC(=C(C=C1)O)O)O)O)O)C1=CC(=C(C=C1)O)O)O
|
| InChi Key |
QFLMUASKTWGRQE-JNIIMKSASA-N
|
| InChi Code |
InChI=1S/C60H50O24/c61-23-13-34(71)42-41(14-23)81-55(20-2-6-26(63)31(68)10-20)51(78)48(42)44-36(73)17-38(75)46-50(53(80)57(83-59(44)46)22-4-8-28(65)33(70)12-22)47-39(76)18-37(74)45-49(52(79)56(84-60(45)47)21-3-7-27(64)32(69)11-21)43-35(72)16-29(66)24-15-40(77)54(82-58(24)43)19-1-5-25(62)30(67)9-19/h1-14,16-18,40,48-57,61-80H,15H2/t40-,48-,49+,50-,51-,52-,53-,54-,55-,56-,57-/m1/s1
|
| Chemical Name |
(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R,4S)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol: ≥ 50 mg/mL (~43.3 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (1.08 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of ethanol stock solution (12.5 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (1.08 mM) (saturation unknown) in 10% EtOH + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of ethanol stock solution (12.5 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8658 mL | 4.3289 mL | 8.6579 mL | |
| 5 mM | 0.1732 mL | 0.8658 mL | 1.7316 mL | |
| 10 mM | 0.0866 mL | 0.4329 mL | 0.8658 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
