| Size | Price | |
|---|---|---|
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Peak serum phosphate concentrations are reached within 4 hours. The generated inorganic phosphate is excreted in the urine. A small amount of glycerophosphate may be excreted unchanged in the urine. Metabolism/Metabolites Glycerophosphate is hydrolyzed to produce inorganic phosphate. The extent of this reaction depends on the activity of serum alkaline phosphatase. Biological Half-Life The elimination half-life of inorganic phosphate is 2.06 hours. |
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| References |
|
| Additional Infomation |
Sodium glycerophosphate is one of several glycerophosphates. Clinically, it is used to treat or prevent hypophosphatemia. Glycerophosphate is hydrolyzed in vivo to inorganic phosphates and glycerol. The extent of this reaction depends on the activity of serum alkaline phosphatase. Sodium glycerophosphate is the sodium salt form of an organic phosphate compound that provides the phosphates required for nutrition. Furthermore, sodium glycerophosphate can be used as a phosphate diluent when the body is contaminated with the beta-ray radioisotope phosphate P-32 (P-32), as P-32 competes with phosphate for absorption. When large doses of sodium glycerophosphate are administered, P-32 absorption can be inhibited or minimized. See also: Anhydrous sodium glycerophosphate (note moved to). Drug Indications Sodium glycerophosphate is indicated as a phosphate source in total parenteral nutrition. It is used in combination with amino acids, glucose, lipid emulsions, and other electrolytes. FDA Label Mechanism of Action Sodium glycerophosphate is used as a donor of inorganic phosphates. For information on the role of phosphates in the body, see [DB09413].
Pharmacodynamics Sodium glycerophosphate provides inorganic phosphates through hydrolysis. |
| Molecular Formula |
C3H7O6PNA2.XH2O
|
|---|---|
| Molecular Weight |
216.0374
|
| Exact Mass |
233.988
|
| CAS # |
154804-51-0
|
| PubChem CID |
22251426
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
102～104 ℃
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
13
|
| Complexity |
117
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
OFNNKPAERNWEDD-UHFFFAOYSA-L
|
| InChi Code |
InChI=1S/C3H9O6P.2Na.H2O/c4-1-3(5)2-9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2
|
| Chemical Name |
disodium;2,3-dihydroxypropyl phosphate;hydrate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 250 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with heating and sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6288 mL | 23.1439 mL | 46.2877 mL | |
| 5 mM | 0.9258 mL | 4.6288 mL | 9.2575 mL | |
| 10 mM | 0.4629 mL | 2.3144 mL | 4.6288 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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