| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
H-HomoArg-OH.HCl targets enzymes and proteins involved in arginine metabolism, protein modification, signal transduction, and biosynthetic pathways. As an analog of arginine, it may interact with nitric oxide synthase, arginase, and other arginine-metabolizing enzymes. It is used to study the role of arginine in various biological processes.
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|---|---|
| ln Vitro |
In vitro, H-HomoArg-OH.HCl is used to study protein modification, signal transduction, and biosynthetic pathways. It serves as a tool for investigating the role of arginine analogs in enzyme inhibition and protein function. Its activity is measured in enzymatic assays and cell-based studies of arginine metabolism.
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| ln Vivo |
In vivo, L-Homoarginine is a naturally occurring amino acid derivative found in trace amounts in the human body. It is not a therapeutic agent but is studied in the context of arginine metabolism and cardiovascular health. Its levels may be altered in certain disease states.
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| Enzyme Assay |
In vitro enzyme assays with H-HomoArg-OH.HCl typically involve studying enzymes of arginine metabolism such as nitric oxide synthase (NOS), arginase, and arginine decarboxylase. The compound is used as a substrate or inhibitor in assays to characterize the activity of these enzymes. Standard assays involve incubating with enzyme preparations and measuring products by spectrophotometric or chromatographic methods.
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| Cell Assay |
In vitro cell culture experiments with H-HomoArg-OH.HCl involve treating various cell types including endothelial cells, macrophages, and neuronal cells. Cells are treated with the compound, and endpoints include assessment of nitric oxide production, arginase activity, cell proliferation, and gene expression. These experiments characterize the effects of homoarginine on cellular function.
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| Animal Protocol |
In vivo animal experiments with H-HomoArg-OH.HCl are not commonly performed as the compound is a research chemical. If used, it would be to study the effects of homoarginine on cardiovascular function, arginine metabolism, or to investigate its role as a biomarker. Its primary significance is in research as a tool for studying arginine metabolism.
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| ADME/Pharmacokinetics |
The pharmacokinetic (PK) properties of H-HomoArg-OH.HCl are not well characterized. As a polar amino acid derivative, it is expected to be absorbed from the gastrointestinal tract and distributed throughout the body. It may be metabolized by enzymes involved in arginine metabolism and excreted in urine. Specific PK data are not available.
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| Toxicity/Toxicokinetics |
H-HomoArg-OH.HCl has a low toxicity profile as an amino acid derivative. For research use, standard laboratory safety practices are sufficient. It is not considered a hazardous substance. Comprehensive toxicology studies have not been published for this compound. It is typically stored as a crystalline powder.
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| Additional Infomation |
H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) is a non-proteinogenic amino acid derivative and guanidino analog of arginine. It is used in biochemical and clinical research to study protein modification, signal transduction, and biosynthetic pathways. The compound is not a drug and has no therapeutic indications. It is available for laboratory research use only.
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| Molecular Formula |
C7H17CLN4O2
|
|---|---|
| Molecular Weight |
224.69
|
| Exact Mass |
188.127
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| CAS # |
1483-01-8
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| Related CAS # |
H-HoArg-OH;156-86-5;L-Homoarginine-13C7,15N4 hydrochloride;2483830-23-3
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| PubChem CID |
2723930
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
414.1±55.0 °C at 760 mmHg
|
| Melting Point |
213-215 °C(lit.)
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| Flash Point |
204.2±31.5 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
|
| Index of Refraction |
1.587
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| LogP |
-1.36
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| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
14
|
| Complexity |
189
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(CCN=C(N)N)C[C@@H](C(=O)O)N.Cl
|
| InChi Key |
YMKBVNVCKUYUDM-JEDNCBNOSA-N
|
| InChi Code |
InChI=1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1
|
| Chemical Name |
(2S)-2-amino-6-(diaminomethylideneamino)hexanoic acid;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 100 mg/mL (445.06 mM)
DMSO: < 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (445.06 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4506 mL | 22.2529 mL | 44.5058 mL | |
| 5 mM | 0.8901 mL | 4.4506 mL | 8.9012 mL | |
| 10 mM | 0.4451 mL | 2.2253 mL | 4.4506 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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