| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Human Endogenous Metabolite
The primary targets of 2,6-diaminoheptanedioic acid are enzymes involved in the lysine biosynthesis pathway in bacteria, such as diaminopimelate decarboxylase and diaminopimelate dehydrogenase. As a component of bacterial cell wall peptidoglycan, it is a target for antibiotics and a potential marker for the quantification of microbial proteins. |
|---|---|
| ln Vitro |
In vitro, 2,6-diaminoheptanedioic acid is used as a marker for the quantification of microbial proteins and to study bacterial cell wall synthesis. It is also used as a constituent of proteoglycans in research on extracellular matrix components. The compound's role as an intermediate in lysine biosynthesis makes it a valuable tool in microbiology and biochemistry.
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| ln Vivo |
In vivo, 2,6-diaminoheptanedioic acid is a component of bacterial cell walls and is essential for microbial metabolism. In animals, it is not synthesized and is obtained from dietary sources or produced by gut microbiota. Its presence in biological samples can indicate bacterial contamination or microbial protein content.
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| Enzyme Assay |
In vitro enzyme assays for 2,6-diaminoheptanedioic acid typically measure the activity of enzymes in the lysine biosynthesis pathway, such as diaminopimelate decarboxylase or diaminopimelate dehydrogenase. The compound is used as a substrate, and the formation of lysine or other products is monitored by chromatographic or spectrophotometric methods to assess enzyme activity and the effects of inhibitors.
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| Cell Assay |
In vitro cell experiments with 2,6-diaminoheptanedioic acid are not extensively documented for mammalian cells, as the compound is primarily relevant to bacterial systems. In bacterial culture studies, the compound is used to study cell wall synthesis and lysine biosynthesis. The growth of bacteria in media containing DAP as a supplement is monitored to assess metabolic activity.
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| Animal Protocol |
In vivo animal experiments with 2,6-diaminoheptanedioic acid are not well-characterized. As a bacterial cell wall component, its presence in animal tissues may indicate bacterial translocation or infection. Studies may involve measuring DAP levels in tissues or body fluids as a marker of bacterial presence or to assess the effects of antibiotics on bacterial cell wall synthesis.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2,6-diaminoheptanedioic acid are limited. As a small, polar amino acid derivative, it is expected to be excreted in urine. In animals, it may be absorbed from the diet or produced by gut microbiota. The compound is stable and has a melting point above 300°C.
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| Toxicity/Toxicokinetics |
Toxicological data for 2,6-diaminoheptanedioic acid are limited. As a naturally occurring amino acid derivative found in bacteria, it is generally considered to have low toxicity. However, comprehensive toxicological studies have not been performed. The compound is intended for research use only.
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| Additional Infomation |
2,6-Diaminopimelic acid is an aminodicarboxylic acid with the structure pimelic acid, containing amino substituents at the C-2 and C-6 positions. It is a metabolite of Escherichia coli. It is both an aminodicarboxylic acid and a dicarboxylic acid fatty acid. Its function is related to pimelic acid. It is the conjugate acid of 2,6-diaminopimelic acid (2-). Diaminopimelic acid is a metabolite found or produced in Escherichia coli (K12 strain, MG1655 strain). It has also been reported to exist in soybeans, Salmonella, and common beans, but relevant data are unclear. It is a diamino derivative of pimelic acid, containing amino groups at the C-2 and C-6 positions, with the general formula (COOH)CH(NH2)CH2CH2CH2CH(NH2)(COOH).
2,6-Diaminoheptanedioic acid is a research compound with applications in microbiology, biochemistry, and cell wall research. It serves as a central intermediate in lysine biosynthesis and a critical component of bacterial cell wall peptidoglycan. As a potential marker for the quantification of microbial proteins, it is valuable in microbial ecology and food science. No clinical trials or approved therapeutic indications exist for this compound. Its mechanism of action is related to its role in bacterial cell wall synthesis and lysine metabolism. |
| Molecular Formula |
C7H14N2O4
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|---|---|
| Molecular Weight |
190.20
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| Exact Mass |
190.095
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| CAS # |
583-93-7
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| PubChem CID |
865
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
426.7±45.0 °C at 760 mmHg
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| Melting Point |
~295 °C (dec.)(lit.)
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| Flash Point |
211.8±28.7 °C
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| Vapour Pressure |
0.0±2.2 mmHg at 25°C
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| Index of Refraction |
1.543
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| LogP |
-1.58
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
13
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| Complexity |
175
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(CC(C(=O)O)N)CC(C(=O)O)N
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| InChi Key |
GMKMEZVLHJARHF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H14N2O4/c8-4(6(10)11)2-1-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
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| Chemical Name |
2,6-diaminoheptanedioic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: 10.42 mg/mL (54.78 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 6.67 mg/mL (35.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2576 mL | 26.2881 mL | 52.5762 mL | |
| 5 mM | 1.0515 mL | 5.2576 mL | 10.5152 mL | |
| 10 mM | 0.5258 mL | 2.6288 mL | 5.2576 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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