| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
| Targets |
The primary targets of S-(2-carboxypropyl)-L-cysteine are metabolic pathways involving glutathione and sulfur-containing amino acids. It is a metabolite of S-(2-carboxypropyl)glutathione and is involved in cellular metabolism and antioxidant defense. As a urinary metabolite, it serves as a marker for certain metabolic disorders.
|
|---|---|
| ln Vitro |
In vitro, S-(2-carboxypropyl)-L-cysteine is used as a reference standard in metabolomics and analytical chemistry for the detection and quantification of sulfur-containing metabolites in biological samples. It is also used in food chemistry research to study flavor formation in Allium species.
|
| ln Vivo |
In vivo, S-(2-carboxypropyl)-L-cysteine is a urinary metabolite. Its presence in urine reflects the metabolism of S-(2-carboxypropyl)glutathione and may indicate underlying metabolic conditions. As a metabolite of Leigh-like syndrome, its levels may be used as a diagnostic marker.
|
| Enzyme Assay |
In vitro enzyme assays for S-(2-carboxypropyl)-L-cysteine typically involve measuring the activity of enzymes involved in glutathione metabolism, such as glutathione S-transferases or gamma-glutamyl transpeptidases. The compound is used as a substrate or product to study the metabolism of glutathione conjugates and the formation of cysteine derivatives.
|
| Cell Assay |
In vitro cell experiments with S-(2-carboxypropyl)-L-cysteine are not extensively documented. The compound may be used in cell culture studies to investigate glutathione metabolism and oxidative stress responses. Its role as a metabolite of glutathione suggests that it may be involved in cellular antioxidant defense mechanisms.
|
| Animal Protocol |
In vivo animal experiments with S-(2-carboxypropyl)-L-cysteine are not well-characterized. As a urinary metabolite, its levels may be measured in animal models of metabolic disorders or glutathione metabolism. Studies may involve administering precursors or modulating glutathione metabolism and measuring the levels of S-(2-carboxypropyl)-L-cysteine in urine.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for S-(2-carboxypropyl)-L-cysteine are limited. As a small, polar amino acid derivative, it is expected to be excreted in urine. It is formed as a metabolite of S-(2-carboxypropyl)glutathione and reflects the turnover of glutathione conjugates. The compound is stable in biological samples and can be detected by LC-MS/MS or other analytical methods.
|
| Toxicity/Toxicokinetics |
Toxicological data for S-(2-carboxypropyl)-L-cysteine are limited. As a naturally occurring metabolite, it is generally considered to have low toxicity. However, elevated levels may indicate metabolic dysfunction. Comprehensive toxicological studies have not been performed. The compound is intended for research use only.
|
| Additional Infomation |
S-(2-Carboxypropyl)cysteine is the (DL)-isomer, a 14C-labeled compound.
S-(2-Carboxypropyl)-L-cysteine is a research compound with applications in metabolomics, food chemistry, and biomarker research. It serves as a metabolic marker of Leigh-like syndrome and as a precursor standard for flavor formation in Allium species. No clinical trials or approved therapeutic indications exist for this compound. Its mechanism of action is related to its role in glutathione metabolism and sulfur-containing amino acid pathways. |
| Molecular Formula |
C7H13NO4S
|
|---|---|
| Molecular Weight |
207.25
|
| Exact Mass |
207.057
|
| CAS # |
6852-42-2
|
| PubChem CID |
151433
|
| Appearance |
White to off-white solid powder
|
| LogP |
0.552
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
13
|
| Complexity |
197
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
CC(CSC[C@@H](C(=O)O)N)C(=O)O
|
| InChi Key |
QSPWUNSFUXUUDG-AKGZTFGVSA-N
|
| InChi Code |
InChI=1S/C7H13NO4S/c1-4(6(9)10)2-13-3-5(8)7(11)12/h4-5H,2-3,8H2,1H3,(H,9,10)(H,11,12)/t4?,5-/m0/s1
|
| Chemical Name |
3-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-methylpropanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 25 mg/mL (120.63 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.06 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.06 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.06 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8251 mL | 24.1255 mL | 48.2509 mL | |
| 5 mM | 0.9650 mL | 4.8251 mL | 9.6502 mL | |
| 10 mM | 0.4825 mL | 2.4125 mL | 4.8251 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
