| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| Other Sizes |
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| Targets |
Human Endogenous Metabolite
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|---|---|
| ln Vivo |
Adrenoleukodystrophy's degree of demyelination is correlated with the behenic acid to behenic acid ratios (C25:0/C22:0 and C26:0/C22:0). The parts that are most affected, where the active process is finished, are mostly home to the intermediate fraction's saturated fatty acids (C24:0, C25:0, and C26:0). The identification of a region with a high concentration of long-chain fatty acids was the cause of the absence of histopathological alterations [1]. The frontal lobe margins are often where areas of myelin loss but axonal retention are most noticeable. lesions. Pentacosanoic acid (C25:0) and hexacanoic acid (C26:0) represent the midpoint of a bell-shaped distribution of very long-chain fatty acids esterified to cholesterol [1].
|
| References | |
| Additional Infomation |
Pentacosanoic acid is a straight-chain saturated fatty acid and a very long-chain fatty acid. It is a conjugate acid of a pentacosanoate.
Pentacosanoic acid has been reported in Senecio scandens, Sabia parviflora, and other organisms with data available. |
| Molecular Formula |
C25H50O2
|
|---|---|
| Molecular Weight |
382.66
|
| Exact Mass |
382.381
|
| CAS # |
506-38-7
|
| PubChem CID |
10468
|
| Appearance |
White to off-white solid powder
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
412.4±8.0 °C at 760 mmHg
|
| Melting Point |
83 °C
|
| Flash Point |
185.0±13.3 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.460
|
| LogP |
11.94
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
23
|
| Heavy Atom Count |
27
|
| Complexity |
288
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
MWMPEAHGUXCSMY-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C25H50O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25(26)27/h2-24H2,1H3,(H,26,27)
|
| Chemical Name |
pentacosanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 5 mg/mL (13.07 mM)
Ethanol: < 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (1.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (1.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6133 mL | 13.0664 mL | 26.1329 mL | |
| 5 mM | 0.5227 mL | 2.6133 mL | 5.2266 mL | |
| 10 mM | 0.2613 mL | 1.3066 mL | 2.6133 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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