Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Purity: = 99.66%
Targets |
STING, IFNβ[1]
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ln Vitro |
There are two different phosphodiester connections in 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium): one connects 2'-OH of GMP and 5'-phosphate of AMP, while the other connects 3'-OH of AMP and 5′-phosphate of GMP(1–2).
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References |
[1]. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.
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Molecular Formula |
C20H22N10NA2O13P2
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Molecular Weight |
718.37
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CAS # |
2734858-36-5
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Related CAS # |
2',3'-cGAMP;1441190-66-4
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SMILES |
OC1([H])[C@@]2([H])COP(O[C@@]3([H])[C@@H](O)[C@H](N4C=NC5=C(N=CN=C45)N)O[C@]3([H])COP(O)(=O)O[C@@]1([H])[C@H](N1C=NC3C(N=C(N)NC1=3)=O)O2)(O)=O.[NaH]
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O: 50 mg/mL (69.60 mM)
DMSO: < 1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: 18.33 mg/mL (25.52 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.3920 mL | 6.9602 mL | 13.9204 mL | |
5 mM | 0.2784 mL | 1.3920 mL | 2.7841 mL | |
10 mM | 0.1392 mL | 0.6960 mL | 1.3920 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.