| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Microbial Metabolite
(R)-(-)-1,2-Propanediol does not have a specific biological target or receptor. As a solvent and excipient, it is not designed to interact with specific pharmacological targets. Its primary role is in formulation chemistry. However, as a chiral compound, it may interact differently with biological systems compared to its (S)-enantiomer, but these effects are typically related to its use as a solvent or a precursor. |
|---|---|
| ln Vitro |
In vitro, (R)-(-)-1,2-Propanediol is used as a solvent and a chemical reagent. It is not typically used for biological activity assays. However, it may be used in cell culture as a cryoprotectant or to study the effects of chiral solvents on biological systems. Its primary in vitro applications are in chemical synthesis and formulation development, where it is valued for its properties as a solvent and a chiral building block.
|
| ln Vivo |
In vivo, (R)-(-)-1,2-Propanediol is used as a component in pharmaceutical formulations, where it acts as a solvent, humectant, or preservative. It is generally recognized as safe for use in pharmaceutical products. It is metabolized in the body to lactic acid and pyruvic acid, which are normal intermediates in carbohydrate metabolism. It is not used as a therapeutic agent itself.
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| Enzyme Assay |
For non-cell-based assays, (R)-(-)-1,2-Propanediol is not used for receptor binding studies. It can be characterized using techniques such as gas chromatography (GC) and polarimetry to determine its enantiomeric purity. It serves as a standard in analytical chemistry for the identification and quantification of chiral diols. Its physicochemical properties, including boiling point, density, and refractive index, are well-characterized.
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| Cell Assay |
For in vitro cellular assays, (R)-(-)-1,2-Propanediol is not typically used as a pharmacological agent. It may be used as a solvent for dissolving lipophilic compounds for cell-based assays. However, its use is limited due to its potential to affect cell viability at high concentrations. It is primarily used in formulation studies rather than as a tool to study cell biology.
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| Animal Protocol |
For in vivo animal studies, (R)-(-)-1,2-Propanediol is not typically used for therapeutic or pharmacological studies. It may be used as an excipient in formulations for animal studies. Its primary applications are in formulation development and as a reference standard. Comprehensive in vivo pharmacological studies are not available for this compound.
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| ADME/Pharmacokinetics |
(R)-(-)-1,2-Propanediol has a molecular weight of 76.09 g/mol and a molecular formula of C3H8O2. It is a colorless, viscous liquid. It is soluble in water and most organic solvents. The compound should be stored in a cool, dry place, away from light. It is commercially available with a purity of ≥97%. It is used in various pharmaceutical and chemical applications.
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| Toxicity/Toxicokinetics |
The toxicity profile of (R)-(-)-1,2-Propanediol is similar to that of propylene glycol, which is generally recognized as safe. It has low acute toxicity. At high doses, it can cause central nervous system depression and lactic acidosis. The compound is for research use only and is not intended for human consumption outside of approved pharmaceutical applications. Standard safety precautions should be observed when handling the compound.
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| References | |
| Additional Infomation |
(R)-Propane-1,2-diol is a propane-1,2-diol. It is a metabolite in both humans and E. coli. It is the enantiomer of (S)-propane-1,2-diol. It is a clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. (R)-Propane-1,2-diol is a metabolite found or produced by E. coli (strains K12 and MG1655). (R)-1,2-propanediol has also been reported in humans and tobacco, with relevant data available. See also: Propylene glycol (note moved here).
(R)-(-)-1,2-Propanediol (CAS 4254-14-2) is the (R)-enantiomer of 1,2-propanediol (propylene glycol). It is a chiral diol widely used as a solvent, extractant, and preservative in various pharmaceutical formulations. It is also used as a chiral building block in organic synthesis. It is available for research purposes only. |
| Molecular Formula |
C3H8O2
|
|---|---|
| Molecular Weight |
76.09
|
| Exact Mass |
76.052
|
| CAS # |
4254-14-2
|
| PubChem CID |
259994
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
184.8±8.0 °C at 760 mmHg
|
| Melting Point |
-60 °C
|
| Flash Point |
107.2±0.0 °C
|
| Vapour Pressure |
0.2±0.8 mmHg at 25°C
|
| Index of Refraction |
1.430
|
| LogP |
-1.34
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
5
|
| Complexity |
20.9
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
O([H])[C@]([H])(C([H])([H])[H])C([H])([H])O[H]
|
| InChi Key |
DNIAPMSPPWPWGF-GSVOUGTGSA-N
|
| InChi Code |
InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
|
| Chemical Name |
(2R)-propane-1,2-diol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (1314.23 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 13.1423 mL | 65.7117 mL | 131.4233 mL | |
| 5 mM | 2.6285 mL | 13.1423 mL | 26.2847 mL | |
| 10 mM | 1.3142 mL | 6.5712 mL | 13.1423 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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