| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| Targets |
1-Tridecanol does not have a defined biological drug target as it is a chemical reagent and fatty alcohol rather than a therapeutic agent. Long-chain fatty alcohols have been studied for various biological activities including antimicrobial properties and effects on membrane fluidity. The compound's hydrophobic nature allows it to interact with lipid membranes, potentially affecting membrane structure and function. However, 1-tridecanol itself is not designed to bind to specific biological targets. Its primary applications are in chemical synthesis and as an industrial intermediate.
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|---|---|
| ln Vitro |
1-Tridecanol is a biochemical reagent that can be utilized in studies pertaining to life sciences as an organic compound or biological material.
As a chemical reagent, 1-Tridecanol is not typically evaluated for direct in vitro biological activity against specific molecular targets. Fatty alcohols in general have been studied for their antimicrobial and membrane-modulating properties, but the parent compound is used primarily as a chemical tool and industrial intermediate rather than a bioactive molecule. Its activity in biological assays would depend on the specific context and concentration, and any observed effects are generally considered incidental. |
| ln Vivo |
In vivo activity data for 1-Tridecanol itself is not available, as the compound is not intended for therapeutic use. Fatty alcohols are used in various industrial and personal care applications, but comprehensive pharmacological studies are not available. The compound's primary applications remain in chemical synthesis and as an industrial intermediate.
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| Enzyme Assay |
Cell-free biochemical assays involving 1-Tridecanol typically focus on its use as a synthetic reagent rather than as an enzyme inhibitor. In organic synthesis, the compound can be used as a building block for the preparation of various derivatives. A standard protocol for esterification involves treating 1-tridecanol with carboxylic acids or acid chlorides in the presence of a catalyst (e.g., acid or base) and a dehydrating agent. The alcohol can also be oxidized to the corresponding aldehyde or carboxylic acid, or converted to other functional groups. The compound's purity is verified by GC. Reactions are monitored by TLC and products are characterized by NMR and mass spectrometry.
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| Cell Assay |
Cell-based assays are not typically performed with 1-Tridecanol as the compound is a chemical reagent and industrial intermediate rather than a drug candidate. If evaluating the biological activity of fatty alcohols or their derivatives, standard cell-based protocols may be used to assess effects on cell membranes or antimicrobial activity. Cells are cultured in appropriate media, treated with varying concentrations of the compound, and cell viability or membrane integrity is assessed. The compound's insolubility in water requires appropriate formulation for cell-based assays.
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| Animal Protocol |
In vivo studies are not typically conducted with 1-Tridecanol itself. The compound is used as an industrial intermediate and in personal care products, but comprehensive in vivo efficacy studies are not available. For drug candidates or bioactive compounds synthesized from this reagent, standard in vivo efficacy studies would be conducted in rodent models of the target disease. The long-chain fatty alcohol moiety may influence the pharmacokinetic properties of the final compound.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
...The permeability of melatonin (MT) reached its maximum when the carbon chain length of the fatty alcohol was 10. The permeability of MT in both porcine and human skin increased with the increase in unsaturation from one double bond to two double bonds. However, permeability decreased when the number of double bonds increased to three. Regression analysis... showed a significant positive correlation between the permeability of saturated fatty alcohols in porcine and human skin (r(2) = 0.8868, P = 0.0005). ...The flux of melatonin in hairless rat skin depended on the carbon chain length of the fatty alcohol, with decanol exhibiting the highest melatonin permeability. Compared to the solvent control group, all fatty alcohols significantly increased transepidermal water loss (TEWL) and skin blood flow. Fatty alcohols (decanol, undecylol, and lauryl alcohol) had a stronger effect on enhancing melatonin permeability, while also leading to increased transepidermal water loss (TEWL), skin blood flow, and exacerbation of erythema. Tridecanol and myristol have weaker penetration-enhancing effects, but cause greater skin irritation. As a chemical reagent rather than a drug, comprehensive pharmacokinetic data for 1-Tridecanol is not available. The molecular weight is 200.36 g/mol. The compound is a solid or viscous liquid at room temperature (melting point 29-34°C) and is insoluble in water but soluble in alcohols and ethers. For fatty alcohols, absorption and metabolism involve oxidation to fatty acids and β-oxidation. The compound's lipophilic nature suggests high tissue distribution and membrane association. |
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in rats: 17.2 ml/kg / Mixed primary isomers / Dermal LD50 in rabbits: 7.07 ml/kg / Mixed primary isomers / Toxicological data for 1-Tridecanol is limited. As with all fatty alcohols and chemical reagents, standard laboratory safety precautions should be observed when handling this compound. The compound is used in personal care products and industrial applications, indicating it is generally considered safe at typical exposure levels. However, ingestion or inhalation of large amounts should be avoided. Appropriate personal protective equipment should be used when handling this chemical. |
| Additional Infomation |
Tridecanol is an oily, colorless liquid with a mild, pleasant odor and floats on water. (US Coast Guard, 1999)
1-Trigecanol is a long-chain primary fatty alcohol, formed by replacing tridecane with a hydroxyl group at the 1-position. It is a bacterial, plant, and human metabolite. It is a Tridecanol and also a long-chain primary fatty alcohol. 1-Trigecanol has been reported to exist in Angelica sinensis, Amorphophallus konjac, and other organisms with relevant data. 1-Tridecanol is a chemical reagent and industrial intermediate rather than an approved pharmaceutical agent. No clinical trials or regulatory approvals exist for therapeutic use of this compound. It is commercially available from various chemical suppliers for research and industrial purposes only. The compound's primary value lies in its utility as a reagent in organic synthesis, including the synthesis of tris(tridecyl) trimellitate (T886455). It is also used in personal care products and as an industrial intermediate. The compound's long-chain fatty alcohol structure makes it useful for studying lipid chemistry and for the synthesis of surfactants, lubricants, and other specialty chemicals. |
| Molecular Formula |
C13H28O
|
|---|---|
| Molecular Weight |
200.36
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| Exact Mass |
200.214
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| CAS # |
112-70-9
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| Related CAS # |
1-Tridecanol-d27;203633-18-5
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| PubChem CID |
8207
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| Appearance |
WATER WHITE LIQ
Crystals from alcohol |
| Density |
0.8±0.1 g/cm3
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| Boiling Point |
272.1±3.0 °C at 760 mmHg
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| Melting Point |
29-34 °C(lit.)
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| Flash Point |
121.1±4.6 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.443
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| LogP |
5.66
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
14
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| Complexity |
91.2
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
XFRVVPUIAFSTFO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
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| Chemical Name |
tridecan-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (499.10 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9910 mL | 24.9551 mL | 49.9102 mL | |
| 5 mM | 0.9982 mL | 4.9910 mL | 9.9820 mL | |
| 10 mM | 0.4991 mL | 2.4955 mL | 4.9910 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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