| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
1-Tridecanol is a biochemical reagent that can be utilized in studies pertaining to life sciences as an organic compound or biological material.
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|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
...The permeability of melatonin (MT) reached its maximum when the carbon chain length of the fatty alcohol was 10. The permeability of MT in both porcine and human skin increased with the increase in unsaturation from one double bond to two double bonds. However, permeability decreased when the number of double bonds increased to three. Regression analysis... showed a significant positive correlation between the permeability of saturated fatty alcohols in porcine and human skin (r(2) = 0.8868, P = 0.0005). ...The flux of melatonin in hairless rat skin depended on the carbon chain length of the fatty alcohol, with decanol exhibiting the highest melatonin permeability. Compared to the solvent control group, all fatty alcohols significantly increased transepidermal water loss (TEWL) and skin blood flow. Fatty alcohols (decanol, undecylol, and lauryl alcohol) had a stronger effect on enhancing melatonin permeability, while also leading to increased transepidermal water loss (TEWL), skin blood flow, and exacerbation of erythema. Tridecanol and myristol have weaker penetration-enhancing effects, but cause greater skin irritation. |
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in rats: 17.2 ml/kg / Mixed primary isomers / Dermal LD50 in rabbits: 7.07 ml/kg / Mixed primary isomers / |
| Additional Infomation |
Tridecanol is an oily, colorless liquid with a mild, pleasant odor and floats on water. (US Coast Guard, 1999)
1-Trigecanol is a long-chain primary fatty alcohol, formed by replacing tridecane with a hydroxyl group at the 1-position. It is a bacterial, plant, and human metabolite. It is a Tridecanol and also a long-chain primary fatty alcohol. 1-Trigecanol has been reported to exist in Angelica sinensis, Amorphophallus konjac, and other organisms with relevant data. |
| Molecular Formula |
C13H28O
|
|---|---|
| Molecular Weight |
200.36
|
| Exact Mass |
200.214
|
| CAS # |
112-70-9
|
| Related CAS # |
1-Tridecanol-d27;203633-18-5
|
| PubChem CID |
8207
|
| Appearance |
WATER WHITE LIQ
Crystals from alcohol |
| Density |
0.8±0.1 g/cm3
|
| Boiling Point |
272.1±3.0 °C at 760 mmHg
|
| Melting Point |
29-34 °C(lit.)
|
| Flash Point |
121.1±4.6 °C
|
| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.443
|
| LogP |
5.66
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
11
|
| Heavy Atom Count |
14
|
| Complexity |
91.2
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
XFRVVPUIAFSTFO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
|
| Chemical Name |
tridecan-1-ol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (499.10 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.48 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9910 mL | 24.9551 mL | 49.9102 mL | |
| 5 mM | 0.9982 mL | 4.9910 mL | 9.9820 mL | |
| 10 mM | 0.4991 mL | 2.4955 mL | 4.9910 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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