| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
|
||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Compared to ammonium chloride infusion, ammonia excretion appears to be faster after ammonium bicarbonate infusion, resulting in higher levels of unionized ammonia in the blood. Metabolism/Metabolites Ammonium bicarbonate dissociates into free ammonia at the cell membrane level. |
|---|---|
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Mouse intravenous LD50: 245 mg/kg |
| Additional Infomation |
Ammonium bicarbonate is a white crystalline solid with an ammonia odor and is readily soluble in water. Its main hazard lies in its environmental threat. Immediate measures should be taken to limit its spread into the environment. Ammonium bicarbonate is used in the manufacture of other ammonium compounds, food processing, and other applications.
Ammonium bicarbonate is an oxygen-containing organic compound. Mechanism of Action The principle behind ammonium bicarbonate's antifungal action is that the bicarbonate anion provides the necessary alkalinity, thereby establishing the free ammonia concentration required for antifungal activity. Therapeutic Uses Antacid and stimulant. Dosage: 0.3-1 gram. /Ammonium Bicarbonate BP/ Veterinary Drugs: Expectorant, used to treat flatulence and colic. Expectorant |
| Molecular Formula |
CH5NO3
|
|---|---|
| Molecular Weight |
79.06
|
| Exact Mass |
79.026
|
| CAS # |
1066-33-7
|
| Related CAS # |
10361-29-2;10361-29-2 (unspecified ammonium salt);40861-29-8 (ammonium-zinc salt)
|
| PubChem CID |
14013
|
| Appearance |
Colorless or white crystals
Shiny, hard, colorless or white prisms or crystalline mass |
| Density |
1,586 g/cm3
|
| Boiling Point |
169.8ºC
|
| Melting Point |
105 °C
|
| Vapour Pressure |
2.58E-05mmHg at 25°C
|
| LogP |
0.546
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
5
|
| Complexity |
24.8
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C(=O)[O-].[N+]([H])([H])([H])[H]
|
| InChi Key |
ATRRKUHOCOJYRX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/CH2O3.H3N/c2-1(3)4;/h(H2,2,3,4);1H3
|
| Chemical Name |
azanium;hydrogen carbonate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 50 mg/mL (632.43 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 12.6486 mL | 63.2431 mL | 126.4862 mL | |
| 5 mM | 2.5297 mL | 12.6486 mL | 25.2972 mL | |
| 10 mM | 1.2649 mL | 6.3243 mL | 12.6486 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
