| Size | Price | Stock | Qty |
|---|---|---|---|
| 1kg |
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| Other Sizes |
| Targets |
N-(Benzyloxycarbonyloxy)succinimide does not have a defined pharmacological target. It is a chemical reagent used primarily in peptide chemistry for the protection of amines, especially useful for the protection of the ε-amino group in lysine and ornithine. The compound is used in the preparation of peptide thioacids and peptide precursors. It is also used in the preparation of aminoglycoside derivatives for the inhibition of topoisomerase in both human and bacterial systems.
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|---|---|
| ln Vitro |
In vitro, N-(Benzyloxycarbonyloxy)succinimide is primarily used as a chemical reagent for peptide synthesis and protein modification. It is a reagent used in the preparation of peptide thioacids and peptide precursors. The compound is also used in the preparation of aminoglycoside derivatives for the inhibition of topoisomerase. It is commonly used as a reagent for the modification of proteins and peptides.
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| ln Vivo |
In vivo activity data for N-(Benzyloxycarbonyloxy)succinimide itself are not available, as the compound is not intended for in vivo administration. It is a chemical reagent used exclusively in vitro for peptide synthesis and protein modification applications. The compound is not designed for therapeutic use and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro enzyme/receptor binding studies, N-(Benzyloxycarbonyloxy)succinimide is not evaluated as a test compound. Instead, it serves as a reagent for the synthesis of test compounds. The compound's properties include a molecular weight of 249.22 g/mol and it is moisture sensitive. It is used in the preparation of aminoglycoside derivatives for topoisomerase inhibition studies.
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| Cell Assay |
For in vitro cell-based experiments, N-(Benzyloxycarbonyloxy)succinimide is not used directly in cell culture. It is a chemical reagent used for the synthesis of compounds that may subsequently be tested in cell-based assays. The compound itself is not evaluated in cell-based assays. Standard cell culture protocols are not applicable for this reagent.
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| Animal Protocol |
In vivo animal studies for N-(Benzyloxycarbonyloxy)succinimide are not applicable, as the compound is a chemical reagent used exclusively for in vitro peptide synthesis and protein modification. No animal studies have been conducted for this compound, and it is not intended for therapeutic or diagnostic use in animals or humans.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for N-(Benzyloxycarbonyloxy)succinimide are not available, as the compound is not a drug and is not administered to living organisms. The compound is a chemical reagent used in peptide synthesis and has no therapeutic applications requiring pharmacokinetic characterization.
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| Toxicity/Toxicokinetics |
N-(Benzyloxycarbonyloxy)succinimide is a research chemical and should be handled with appropriate laboratory safety precautions. As a succinimide derivative, it may pose risks of skin and eye irritation. The compound is moisture sensitive and should be stored in a dry environment. Specific LD₅₀ values, acute toxicity classifications, and chronic toxicity data are not available in the public literature. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| Additional Infomation |
N-(Benzyloxycarbonyloxy)succinimide (Z-OSu, CAS 13139-17-8) is a research-grade chemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are in peptide synthesis for the protection of amines, especially the ε-amino group in lysine and ornithine. The compound is used in the preparation of peptide thioacids and peptide precursors, as well as in the preparation of aminoglycoside derivatives for topoisomerase inhibition. It is available from chemical suppliers for laboratory research use only. No clinical trials or approved indications exist for this compound.
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| Molecular Formula |
C12H11NO5
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|---|---|
| Molecular Weight |
249.22
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| Exact Mass |
249.063
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| CAS # |
13139-17-8
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| PubChem CID |
83172
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
369.0±35.0 °C at 760 mmHg
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| Melting Point |
80-82 °C(lit.)
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| Flash Point |
177.0±25.9 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.583
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| LogP |
0.42
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
18
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| Complexity |
332
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C(=O)OC([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N1C(C([H])([H])C([H])([H])C1=O)=O
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| InChi Key |
MJSHDCCLFGOEIK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H11NO5/c14-10-6-7-11(15)13(10)18-12(16)17-8-9-4-2-1-3-5-9/h1-5H,6-8H2
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| Chemical Name |
benzyl (2,5-dioxopyrrolidin-1-yl) carbonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (401.25 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.03 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0125 mL | 20.0626 mL | 40.1252 mL | |
| 5 mM | 0.8025 mL | 4.0125 mL | 8.0250 mL | |
| 10 mM | 0.4013 mL | 2.0063 mL | 4.0125 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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