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| Other Sizes |
| Targets |
1,4-Diiodobenzene has been described as an anti-retroviral drug used in the treatment of HIV infection, with activity against proteases and integrase in HIV-1. However, this information appears to be erroneous as 1,4-diiodobenzene is primarily a synthetic intermediate rather than an approved drug. The compound does not have a well-defined pharmacological target and is used primarily as a chemical reagent and building block for organic synthesis.
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| ln Vitro |
In vitro, 1,4-Diiodobenzene is primarily used as a chemical reagent and synthetic intermediate. It is employed in the synthesis of various pharmaceutical compounds that are subsequently tested in in vitro assays. The compound is soluble in DMSO, ethanol, and DMF. As a diiodinated arene, it is a common building block for cross-coupling reactions such as Suzuki-Miyaura and Sonogashira couplings for the construction of drug-like molecules.
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| ln Vivo |
In vivo activity data for 1,4-Diiodobenzene itself are not available, as the compound is not intended for direct in vivo administration. Rather, it is a precursor used in the synthesis of drug candidates that are subsequently evaluated in animal models. The compound's in vivo relevance is indirect, through the biological activities of the final pharmaceutical compounds derived from it.
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| Enzyme Assay |
For in vitro enzyme/receptor binding studies, 1,4-Diiodobenzene is not typically evaluated as a test compound itself. Instead, it serves as a reagent for the synthesis of test compounds. The compound's properties include a molecular weight of 329.91 g/mol and a logP of 4.11, indicating high lipophilicity. The two iodine atoms provide versatile handles for cross-coupling reactions in medicinal chemistry.
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| Cell Assay |
For in vitro cell-based experiments, 1,4-Diiodobenzene is used as an intermediate in the synthesis of compounds that are tested in cell viability, proliferation, and cytotoxicity assays. The compound itself is not typically evaluated in cell-based assays. Standard cell culture protocols for test compounds synthesized from this intermediate involve dissolving the final product in DMSO and diluting to working concentrations in appropriate cell culture medium.
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| Animal Protocol |
In vivo animal studies using 1,4-Diiodobenzene are conducted on the final drug compounds synthesized from it, not on the intermediate itself. For pharmaceutical candidates derived from this building block, efficacy studies would typically be performed in mouse models of the relevant disease. Standard in vivo protocols involve administration to rodents via oral gavage or intraperitoneal injection, with appropriate pharmacokinetic and pharmacodynamic endpoints.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 1,4-Diiodobenzene as a standalone compound are not characterized in the literature. The compound has a molecular weight of 329.91 g/mol and a logP of 4.11, suggesting high lipophilicity and potential for membrane permeability. However, the high molecular weight may limit oral bioavailability. Empirical pharmacokinetic data are not available for this intermediate compound.
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| Toxicity/Toxicokinetics |
1,4-Diiodobenzene is a research chemical and should be handled with appropriate laboratory safety precautions. As an iodinated aromatic compound, it may pose risks of skin and eye irritation. The compound requires protection from light during transportation and storage. Specific LD₅₀ values and acute toxicity classifications are not available in the public literature. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| Additional Infomation |
1,4-Diiodobenzene (CAS 624-38-4) is primarily a research-grade chemical intermediate, not an FDA-approved pharmaceutical drug. Its primary applications are in organic synthesis as a building block for cross-coupling reactions. The two iodine atoms provide versatile handles for introducing diverse substituents via palladium-catalyzed coupling reactions. The compound is used in the synthesis of various pharmaceutical compounds and in materials science. No clinical trials or approved indications exist for this compound. It is intended for laboratory research use only.
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| Molecular Formula |
C6H4I2
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|---|---|
| Molecular Weight |
329.91
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| Exact Mass |
329.84
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| CAS # |
624-38-4
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| Related CAS # |
1,4-Diiodobenzene-d4
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| PubChem CID |
12208
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| Appearance |
Off-white to light yellow solid powder
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| Density |
2.5±0.1 g/cm3
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| Boiling Point |
285.0±0.0 °C at 760 mmHg
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| Melting Point |
131-133 °C(lit.)
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| Flash Point |
137.7±15.3 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.708
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| LogP |
4.11
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
54.9
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC(=CC=C1I)I
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| InChi Key |
LFMWZTSOMGDDJU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H4I2/c7-5-1-2-6(8)4-3-5/h1-4H
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| Chemical Name |
1,4-diiodobenzene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~303.1 mM; with ultrasonication)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0311 mL | 15.1556 mL | 30.3113 mL | |
| 5 mM | 0.6062 mL | 3.0311 mL | 6.0623 mL | |
| 10 mM | 0.3031 mL | 1.5156 mL | 3.0311 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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