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| Other Sizes |
| Targets |
p-Dimethylaminobenzaldehyde does not have a defined pharmacological target. It is a chemical reagent used primarily for analytical and synthetic applications. The compound is known as Ehrlich's reagent and is used as a reagent for the detection of arsphenamine, antipyrine, indole, skatole, indican, tryptophan, albumin, ergot alkaloids, colon bacteria, and for differentiating between serum eruptions and true scarlet fever.
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|---|---|
| ln Vitro |
In vitro, p-Dimethylaminobenzaldehyde is primarily used as a chemical reagent. It is used in the manufacture of dyes and as a reagent for various analytical applications including the detection of indole, skatole, tryptophan, and other compounds. The compound is also used as a hydrogen bond acceptor in deep eutectic solvent synthesis and urea derivatization for analytical applications.
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| ln Vivo |
In vivo data for p-Dimethylaminobenzaldehyde are not available, as the compound is a chemical reagent used for analytical and synthetic applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile. The compound is not designed for therapeutic use.
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| Enzyme Assay |
For in vitro analytical assays, p-Dimethylaminobenzaldehyde is used as a colorimetric reagent. The compound reacts with indole and pyrrole derivatives to produce colored products (Ehrlich's reaction). The assay typically involves mixing the sample with the reagent in acidic conditions and measuring absorbance at specific wavelengths. The compound is also used in the quantitative determination of various analytes including tryptophan, indican, and ergot alkaloids.
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| Cell Assay |
For in vitro cell-based experiments, p-Dimethylaminobenzaldehyde is not typically used directly in cell culture. It is a chemical reagent used for analytical and synthetic applications. The compound may be used in the preparation of staining reagents or in the analysis of cell culture samples, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for p-Dimethylaminobenzaldehyde are not applicable, as the compound is a chemical reagent used for analytical and synthetic applications. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for p-Dimethylaminobenzaldehyde are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 149.19 g/mol, a melting point of 70-74°C, a boiling point of 176-177°C, and a density of 1.1±0.1 g/cm³. It is light sensitive and should be protected from light.
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| Toxicity/Toxicokinetics |
p-Dimethylaminobenzaldehyde is a research chemical and should be handled with appropriate laboratory safety precautions. As an aromatic aldehyde, it may cause skin and eye irritation. The compound is light sensitive and incompatible with bases and strong oxidizing agents. Specific LD₅₀ values and acute toxicity classifications are available from safety data sheets. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| References | |
| Additional Infomation |
4-(dimethylamino)benzaldehyde is a benzaldehyde compound with a structure in which a dimethylamino substituent is introduced at the 4-position of benzaldehyde. It can be used as an indicator for indole and hydrazine, exhibiting colorimetric properties. It belongs to the benzaldehyde class, substituted aniline, and tertiary amine compounds.
p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde, DMAB, CAS 100-10-7) is a research-grade chemical reagent, not an FDA-approved pharmaceutical drug. It is widely known as Ehrlich's reagent and is used in the manufacture of dyes and as a reagent for the detection of various compounds including indole, skatole, tryptophan, and ergot alkaloids. The compound is also used as a hydrogen bond acceptor in deep eutectic solvent synthesis. No clinical trials or approved indications exist for this compound. |
| Molecular Formula |
C9H11NO
|
|---|---|
| Molecular Weight |
149.19
|
| Exact Mass |
149.084
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| CAS # |
100-10-7
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| PubChem CID |
7479
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| Appearance |
Light blue to light purple solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
176-177 ºC (17 mmHg)
|
| Melting Point |
74 °C
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| Flash Point |
164 ºC
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.596
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| LogP |
1.81
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
126
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CN(C)C1=CC=C(C=C1)C=O
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| InChi Key |
BGNGWHSBYQYVRX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H11NO/c1-10(2)9-5-3-8(7-11)4-6-9/h3-7H,1-2H3
|
| Chemical Name |
4-(dimethylamino)benzaldehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (670.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.76 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.76 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.76 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7029 mL | 33.5143 mL | 67.0286 mL | |
| 5 mM | 1.3406 mL | 6.7029 mL | 13.4057 mL | |
| 10 mM | 0.6703 mL | 3.3514 mL | 6.7029 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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