| Size | Price | Stock | Qty |
|---|---|---|---|
| 500g |
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| Other Sizes |
| Targets |
2,3,5-Trichloropyridine derivatives are recognized for their herbicidal activity. The compound does not have a defined pharmacological target for therapeutic applications but serves as a building block for agrochemicals. As a chlorinated pyridine, it can be used in the synthesis of various biologically active compounds, including herbicides and pharmaceuticals.
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|---|---|
| ln Vitro |
In vitro, 2,3,5-trichloropyridine is primarily used as a chemical reagent and synthetic intermediate. It serves as a crucial building block for the synthesis of various compounds. The compound's derivatives are recognized for their herbicidal activity, making it valuable for specific chemical synthesis and research applications. As a biochemical reagent, it is used in life science research.
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| ln Vivo |
In vivo data for 2,3,5-trichloropyridine as a therapeutic agent are not available, as the compound is primarily a chemical intermediate and agrochemical building block. Its derivatives have herbicidal activity, but the compound itself is not intended for therapeutic administration. The compound's in vivo relevance is primarily in the context of agrochemical applications.
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| Enzyme Assay |
For in vitro chemical synthesis, 2,3,5-trichloropyridine is used as a building block for the synthesis of herbicidal compounds and other derivatives. Standard protocols involve reacting the trichloropyridine with appropriate reagents to introduce various substituents through nucleophilic aromatic substitution or cross-coupling reactions. The compound's three chlorine atoms provide multiple handles for derivatization.
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| Cell Assay |
For in vitro cell-based experiments, 2,3,5-trichloropyridine is not typically used directly in cell culture. It is a chemical intermediate used for organic synthesis and agrochemical research. The compound may be used in the synthesis of compounds that are subsequently tested in biological assays, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for 2,3,5-trichloropyridine are not applicable for therapeutic purposes. The compound may be used in agrochemical studies to evaluate the herbicidal activity of its derivatives in plant models. Standard in vivo protocols in plant models involve application to plants and measurement of herbicidal effects.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2,3,5-trichloropyridine as a drug candidate are not available, as the compound is not intended for therapeutic administration. The compound has a molecular weight of 182.44 g/mol. As a chlorinated pyridine, it is expected to have moderate lipophilicity and may be subject to metabolic dechlorination. The compound is primarily used as a reagent rather than as a drug candidate.
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| Toxicity/Toxicokinetics |
2,3,5-Trichloropyridine is a research chemical and should be handled with appropriate laboratory safety precautions. As a chlorinated compound, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values, acute toxicity classifications, and chronic toxicity data are not available in the public literature. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| Additional Infomation |
2,3,5-Trichloropyridine (CAS 16063-70-0) is primarily a research-grade chemical intermediate, not an FDA-approved pharmaceutical drug. Its primary applications are as a crucial building block for organic synthesis and agrochemical research. Its derivatives are recognized for their herbicidal activity. No clinical trials or approved therapeutic indications exist for this compound.
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| Molecular Formula |
C5H2CL3N
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|---|---|
| Molecular Weight |
182.44
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| Exact Mass |
180.925
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| CAS # |
16063-70-0
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| PubChem CID |
27666
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| Appearance |
White to light brown solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
215.7±35.0 °C at 760 mmHg
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| Melting Point |
46-50 °C(lit.)
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| Flash Point |
104.7±11.5 °C
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| Vapour Pressure |
0.2±0.4 mmHg at 25°C
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| Index of Refraction |
1.573
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| LogP |
2.9
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
9
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| Complexity |
98.2
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=C(C=NC(=C1Cl)Cl)Cl
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| InChi Key |
CNLIIAKAAMFCJG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H2Cl3N/c6-3-1-4(7)5(8)9-2-3/h1-2H
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| Chemical Name |
2,3,5-trichloropyridine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (548.13 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4813 mL | 27.4063 mL | 54.8125 mL | |
| 5 mM | 1.0963 mL | 5.4813 mL | 10.9625 mL | |
| 10 mM | 0.5481 mL | 2.7406 mL | 5.4813 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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