| Size | Price | |
|---|---|---|
| Other Sizes |
| Toxicity/Toxicokinetics |
Interactions
Large doses of zinc may inhibit copper absorption in the intestine; zinc supplements should be taken at least 2 hours after the administration of copper supplements. /Zinc supplements/ Thiazide diuretics have been found to increase urinary zinc excretion. /Zinc supplements/ Concurrent use of large amounts of fiber, phosphorus, or phytates with zinc supplements may reduce zinc absorption by formation of nonabsorbable complexes; food containing fiber, phosphorus, or phytates should be taken at least 2 hours after zinc supplements. /Zinc supplements/ Some studies have found that folate can decrease the absorption of zinc, but not in the presence of excessive zinc; other studies have found no inhibition. /Zinc supplements/ For more Interactions (Complete) data for ZINC GLUCONATE (8 total), please visit the HSDB record page. |
|---|---|
| References | |
| Additional Infomation |
Therapeutic Uses
MEDICATION (VET): CATTLE DERMATOMYCOSIS, CAUSED BY TRICHOPHYTON VERRUCOSUM (TRICHOPHYTOSIS) WAS TREATED BY ORAL ADMIN OF PREPN CONTAINING 20-70% ZINC GLUCONATE, 2-10% SULFUR, 0.2-1% VITAMIN A (106 IU), 2-6% METHIONINE, & INERT CARRIER SUCH AS CALCIUM CARBONATE OR FLOUR. DIETARY SUPPLEMENT & FOOD ADDITIVE; VITAMIN TABLETS EXPTL USE: ZINC GLUCONATE ADDED TO SUBOPTIMAL DOSES OF ORTHO-GYNOL JELLY OR DELFEN CREAM IMPROVES VAGINAL CONTRACEPTIVE EFFICACY OF THESE PRODUCTS. EXPTL USE: TOXIC BLOOD LEAD LEVELS IN WORKERS DECR FROM 61.6 TO 46.0 UG/100 ML AFTER 24 WK TREATMENT WITH VITAMIN C & ZINC (2 G & 60 MG, DAILY). HEMOGLOBIN LEVELS INCR SIGNIFICANTLY & SERUM & WHOLE BLOOD COPPER LEVELS DECREASED FOLLOWING TREATMENT. For more Therapeutic Uses (Complete) data for ZINC GLUCONATE (8 total), please visit the HSDB record page. Drug Warnings A potential role for zinc in retarding the progression of age-related macular degeneration has not been proven. Zinc salts have not been found to be beneficial in the treatment of acute intermittent porphyria. /Zinc supplements/ Zinc injection that contains benzyl alcohol as a preservative should not be used in newborn and immature infants. The use of benzyl alcohol in neonates has been associated with a fatal toxic syndrome consisting of metabolic acidosis and CNS, respiratory, circulatory, and renal function impairment. /Zinc supplements/ Pharmacodynamics Zinc is an important mineral found in almost every cell in the human body. It promotes the activity of about 100 enzymes. Zinc deficiency is often associated with an increased risk of infection. When they are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement. |
| Molecular Formula |
C12H22O14ZN
|
|---|---|
| Molecular Weight |
455.67
|
| Exact Mass |
454.03
|
| CAS # |
4468-02-4
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
673.6ºC at 760 mmHg
|
| Melting Point |
131ºC
|
| Flash Point |
375.2ºC
|
| SMILES |
C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O.[Zn]
|
| InChi Key |
ZSKINHGFQOKUDM-IYEMJOQQSA-N
|
| InChi Code |
InChI=1S/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/t2*2-,3-,4+,5-;/m11./s1
|
| Chemical Name |
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid;zinc
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 50 mg/mL (109.73 mM)
DMSO: 50 mg/mL (109.73 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.49 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.49 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1946 mL | 10.9729 mL | 21.9457 mL | |
| 5 mM | 0.4389 mL | 2.1946 mL | 4.3891 mL | |
| 10 mM | 0.2195 mL | 1.0973 mL | 2.1946 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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