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| Other Sizes |
| Targets |
N,O-Dimethylhydroxylamine hydrochloride does not have a defined pharmacological target. It is a chemical reagent used for the conversion of carbonyl compounds to oximes and in other organic synthesis processes. Its mechanism of action is chemical, involving nucleophilic attack on carbonyl groups or participation in methylation reactions.
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| ln Vitro |
In vitro, N,O-dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. As a hydrochloride salt, it offers enhanced solubility, facilitating its integration into diverse chemical processes. It is a common reagent in medicinal chemistry for the synthesis of Weinreb amides.
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| ln Vivo |
In vivo activity data for N,O-dimethylhydroxylamine hydrochloride are not available, as the compound is a chemical reagent used for in vitro synthesis. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro chemical synthesis, N,O-dimethylhydroxylamine hydrochloride is used as a reagent for the conversion of carbonyl compounds to oximes. Standard protocols involve dissolving the compound in an appropriate solvent (e.g., pyridine, methanol) and adding it to the carbonyl compound. The reaction mixture is stirred at room temperature or under reflux, and the product is isolated by standard workup procedures. The compound is also used in the preparation of Weinreb amides from carboxylic acids.
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| Cell Assay |
For in vitro cell-based experiments, N,O-dimethylhydroxylamine hydrochloride is not typically used directly in cell culture. It is a chemical reagent used for organic synthesis. The compound may be used in the synthesis of compounds that are subsequently tested in cell-based assays, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for N,O-dimethylhydroxylamine hydrochloride are not applicable, as the compound is a chemical reagent used for organic synthesis. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for N,O-dimethylhydroxylamine hydrochloride are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 97.54 g/mol and a melting point of 115-116°C. As a hydrochloride salt, it is highly water-soluble but would be rapidly metabolized or excreted if administered systemically.
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| Toxicity/Toxicokinetics |
N,O-Dimethylhydroxylamine hydrochloride is a research chemical and should be handled with appropriate laboratory safety precautions. As a hydrochloride salt, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values and acute toxicity classifications are not available in the public literature.
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| Additional Infomation |
N,O-Dimethylhydroxylamine hydrochloride (CAS 6638-79-5) is a research-grade chemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are in organic synthesis for the conversion of carbonyl compounds to oximes, as a methylating agent, and in the preparation of Weinreb amides. No clinical trials or approved therapeutic indications exist for this compound.
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| Molecular Formula |
C2H8CLNO
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|---|---|
| Molecular Weight |
97.54
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| Exact Mass |
97.029
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| CAS # |
6638-79-5
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| PubChem CID |
81138
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| Appearance |
White to off-white solid powder
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| Density |
1 g/cm3
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| Boiling Point |
2.9ºC at 760 mmHg
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| Melting Point |
112-115 °C
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| LogP |
0.96
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
5
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| Complexity |
10
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl[H].O(C([H])([H])[H])N([H])C([H])([H])[H]
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| InChi Key |
USZLCYNVCCDPLQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C2H7NO.ClH/c1-3-4-2;/h3H,1-2H3;1H
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| Chemical Name |
N-methoxymethanamine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (1025.22 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (25.63 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (25.63 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (25.63 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 10.2522 mL | 51.2610 mL | 102.5220 mL | |
| 5 mM | 2.0504 mL | 10.2522 mL | 20.5044 mL | |
| 10 mM | 1.0252 mL | 5.1261 mL | 10.2522 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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