| Size | Price | Stock | Qty |
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| 10g |
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| 25g |
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| 50g |
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| Other Sizes |
| Targets |
Tryptamine hydrochloride acts as a non-selective serotonin receptor agonist and as a serotonin-norepinephrine-dopamine releasing agent (SNDRA). It is an analogue of the amino acid tryptophan and has psychoactive properties, functioning as a neurotransmitter in the body that affects mood, perception, and cognition. The compound's mechanism of action involves binding to and activating serotonin receptors.
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| ln Vitro |
In study pertaining to life sciences, tryptamine (hydrochloride) is a biochemical reagent that can be utilized as an organic substance or biological material.
In vitro, tryptamine hydrochloride is used as a research chemical and as a starting material for the synthesis of other organic and chemical reagents. It is a reactant for the preparation of tryptamine derivatives as inhibitors against hepatitis B virus and carbamoyl epipodophyllotoxins as potential antitumor agents. The compound's indole scaffold makes it a valuable building block for the synthesis of various biologically active molecules. |
| ln Vivo |
In vivo data for tryptamine hydrochloride as a therapeutic agent are limited. As a psychoactive compound, it is known to affect mood, perception, and cognition through its action on serotonin receptors. However, the compound is primarily used as a research chemical rather than as a therapeutic agent. Its hydrochloride salt form is widely used as a research chemical and as a starting material for synthesis.
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| Enzyme Assay |
For in vitro receptor binding assays, tryptamine hydrochloride can be evaluated for its affinity at serotonin receptors. Standard protocols involve incubating the compound with membrane preparations from cells expressing serotonin receptors and measuring displacement of a radiolabeled ligand (e.g., [³H]-LSD or [³H]-serotonin). IC₅₀ and Ki values are calculated from competition binding curves. The compound's activity as a serotonin-norepinephrine-dopamine releasing agent can be assessed using neurotransmitter uptake inhibition assays.
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| Cell Assay |
For in vitro cell-based experiments, tryptamine hydrochloride can be evaluated for its effects on serotonin receptor signaling. Cells expressing serotonin receptors are treated with the compound at various concentrations, and downstream signaling pathways (e.g., cAMP accumulation, calcium mobilization) are measured. The compound's psychoactive properties make it useful for studying serotonin receptor pharmacology. Standard cell culture protocols involve dissolving the compound in DMSO and diluting to working concentrations.
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| Animal Protocol |
In vivo animal studies using tryptamine hydrochloride are typically conducted in models of psychoactive drug effects. Standard protocols involve administration to rodents via intraperitoneal or intravenous injection, followed by behavioral testing to assess effects on locomotion, anxiety, and other behaviors. The compound's effects on serotonin receptor signaling can be measured by assessing changes in neurotransmitter levels and receptor occupancy.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of tryptamine hydrochloride are characterized in the context of its use as a research chemical. As a small, polar molecule (MW 196.68 g/mol), it is expected to have reasonable oral bioavailability and blood-brain barrier permeability. The compound is metabolized by monoamine oxidase (MAO) and other enzymes. The hydrochloride salt form enhances aqueous solubility for research applications. Empirical pharmacokinetic data are available from toxicology studies.
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| Toxicity/Toxicokinetics |
Tryptamine hydrochloride is a research chemical and should be handled with appropriate laboratory safety precautions. As a psychoactive compound, it may have central nervous system effects and should be handled with care. The compound is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values and acute toxicity classifications are available from safety data sheets. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| Additional Infomation |
Tryptamine hydrochloride (CAS 343-94-2) is primarily a research-grade chemical and biochemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are as a research chemical for studying serotonin receptor pharmacology, as a starting material for the synthesis of tryptamine derivatives, and as a precursor for the synthesis of biologically active compounds. No clinical trials or approved therapeutic indications exist for this compound.
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| Molecular Formula |
C10H13CLN2
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|---|---|
| Molecular Weight |
196.68
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| Exact Mass |
196.076
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| CAS # |
343-94-2
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| Related CAS # |
Tryptamine;61-54-1;Tryptamine-d2 hydrochloride;362049-48-7
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| PubChem CID |
67652
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| Appearance |
White to off-white solid powder
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| Density |
1.157g/cm3
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| Boiling Point |
378.8ºC at 760mmHg
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| Melting Point |
253-255 °C(lit.)
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| Flash Point |
187.7ºC
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| LogP |
3.171
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
13
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| Complexity |
147
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl[H].N1([H])C([H])=C(C([H])([H])C([H])([H])N([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
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| InChi Key |
KDFBGNBTTMPNIG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H12N2.ClH/c11-6-5-8-7-12-10-4-2-1-3-9(8)10;/h1-4,7,12H,5-6,11H2;1H
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| Chemical Name |
2-(1H-indol-3-yl)ethanamine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (508.44 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0844 mL | 25.4220 mL | 50.8440 mL | |
| 5 mM | 1.0169 mL | 5.0844 mL | 10.1688 mL | |
| 10 mM | 0.5084 mL | 2.5422 mL | 5.0844 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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