| Size | Price | Stock | Qty |
|---|---|---|---|
| 2g |
|
||
| 5g |
|
||
| Other Sizes |
| Targets |
4,4'-Diamino-2,2'-bipyridine does not have a defined pharmacological target. It is a bidentate chelator that forms stable complexes with metal ions. The compound's functional capacity allows it to coordinate effectively with metals, making it a valuable component in various chemical processes and applications where metal binding is essential. It is used as a ligand in coordination chemistry.
|
|---|---|
| ln Vitro |
For life science-related study, (NH2)2bpy is a biochemical reagent that can be utilized as an organic substance or biological material.
In vitro, 4,4'-diamino-2,2'-bipyridine is used as a bidentate chelator and chemical intermediate. It is used to form stable complexes with metal ions for various applications. As a bipyridine ligand, it is used in coordination chemistry, catalysis, and materials science. The amino groups provide handles for further derivatization, enabling the synthesis of functionalized metal complexes. |
| ln Vivo |
In vivo activity data for 4,4'-diamino-2,2'-bipyridine are not available, as the compound is a ligand and chelator used for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile. The compound is not designed for therapeutic use.
|
| Enzyme Assay |
For in vitro coordination chemistry, 4,4'-diamino-2,2'-bipyridine is used as a ligand to form metal complexes. Standard protocols involve dissolving the compound in an appropriate solvent (e.g., ethanol, acetonitrile) and reacting it with metal salts (e.g., RuCl₃, FeCl₂) to form coordination complexes. The complexes are characterized by UV-Vis spectroscopy, NMR, and mass spectrometry. The compound's bidentate nature allows it to chelate metal ions effectively.
|
| Cell Assay |
For in vitro cell-based experiments, 4,4'-diamino-2,2'-bipyridine is not typically used directly in cell culture. It is a chemical reagent used for coordination chemistry and organic synthesis. The compound may be used in the synthesis of metal complexes that are subsequently tested in cell-based assays, but it is not added directly to cell cultures as a test compound.
|
| Animal Protocol |
In vivo animal studies for 4,4'-diamino-2,2'-bipyridine are not applicable, as the compound is a ligand and chelator used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for 4,4'-diamino-2,2'-bipyridine are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 186.22 g/mol. As a bipyridine derivative, it is expected to have moderate lipophilicity and may bind to metal ions in biological systems. The compound is primarily used as a reagent rather than as a drug candidate.
|
| Toxicity/Toxicokinetics |
4,4'-Diamino-2,2'-bipyridine is a research chemical and should be handled with appropriate laboratory safety precautions. As a nitrogen-containing heterocycle, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values, acute toxicity classifications, and chronic toxicity data are not available in the public literature. Standard safety practices include the use of personal protective equipment and working in a fume hood.
|
| Additional Infomation |
4,4'-Diamino-2,2'-bipyridine ((NH₂)₂bpy, CAS 18511-69-8) is primarily a research-grade chemical ligand and chelator, not an FDA-approved pharmaceutical drug. Its primary applications are as a bidentate chelator for forming stable metal complexes and as a ligand in coordination chemistry and catalysis. No clinical trials or approved therapeutic indications exist for this compound.
|
| Molecular Formula |
C10H10N4
|
|---|---|
| Molecular Weight |
186.21
|
| Exact Mass |
186.09
|
| CAS # |
18511-69-8
|
| PubChem CID |
191515
|
| Appearance |
Off-white to gray solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
521.0±50.0 °C at 760 mmHg
|
| Flash Point |
301.9±17.3 °C
|
| Vapour Pressure |
0.0±1.4 mmHg at 25°C
|
| Index of Refraction |
1.687
|
| LogP |
-0.2
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
14
|
| Complexity |
165
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
N1C([H])=C([H])C(=C([H])C=1C1C([H])=C(C([H])=C([H])N=1)N([H])[H])N([H])[H]
|
| InChi Key |
WTHJTVKLMSJXEV-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H10N4/c11-7-1-3-13-9(5-7)10-6-8(12)2-4-14-10/h1-6H,(H2,11,13)(H2,12,14)
|
| Chemical Name |
2-(4-aminopyridin-2-yl)pyridin-4-amine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (537.03 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.3703 mL | 26.8514 mL | 53.7028 mL | |
| 5 mM | 1.0741 mL | 5.3703 mL | 10.7406 mL | |
| 10 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
