| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| Targets |
1-Thioglycerol does not have a defined pharmacological target. It is a thiol-containing molecule essential for studying redox reactions, protein thiolation, and as a stabilizer in various biochemical assays. Its mechanism of action involves the thiol group (-SH) participating in redox reactions, forming disulfide bonds, and protecting proteins and enzymes from oxidative damage. The compound is used as a reducing agent and antioxidant in biochemical applications.
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|---|---|
| ln Vitro |
1-Thioglycerol is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic compound or biological material.
In vitro, 1-thioglycerol is used as a reducing agent and antioxidant in biochemical assays. It is used to protect proteins and enzymes from oxidative damage by maintaining a reducing environment. The compound is also used in studies of redox reactions and protein thiolation. It is used as a stabilizer in various biochemical assays and as a reagent in organic synthesis. |
| ln Vivo |
In vivo data for 1-thioglycerol as a therapeutic agent are not available. The compound is primarily used as a biochemical reagent and reducing agent for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile. The compound is not designed for therapeutic use.
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| Enzyme Assay |
For in vitro biochemical assays, 1-thioglycerol is used as a reducing agent to maintain a reducing environment. Standard protocols involve adding the compound to assay buffers at concentrations typically ranging from 1-10 mM. The compound's ability to reduce disulfide bonds and protect proteins from oxidation is assessed using standard biochemical assays. It is also used as a stabilizer in enzyme preparations and protein solutions.
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| Cell Assay |
For in vitro cell-based experiments, 1-thioglycerol is not typically used directly in cell culture as a test compound. It is a biochemical reagent used as a reducing agent and stabilizer in cell lysis buffers and protein extraction solutions. The compound may be used in the preparation of samples for downstream analyses, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for 1-thioglycerol are not applicable, as the compound is a biochemical reagent used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 1-thioglycerol are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 108.16 g/mol. As a small, polar thiol, it would be expected to have rapid metabolism and excretion if administered systemically. The compound is primarily used as a reagent rather than as a drug candidate.
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| Toxicity/Toxicokinetics |
1-Thioglycerol is a research chemical and should be handled with appropriate laboratory safety precautions. As a thiol, it has a characteristic odor and may cause skin and eye irritation. The compound is hygroscopic and should be stored at 2-8°C under an inert atmosphere. It is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values and acute toxicity classifications are not available.
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| Additional Infomation |
Monothioglycerol is a thiol formed when a primary hydroxyl group in the glycerol molecule is replaced by a thiol group. It acts as a wound-healing agent and a reducing agent. It is a thiol and a member of the propane-1,2-diol class of compounds.
1-Thioglycerol (α-Thioglycerol, CAS 96-27-5) is primarily a research-grade biochemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are as a reducing agent and antioxidant in biochemical assays, for studying redox reactions and protein thiolation, and as a stabilizer in various biochemical applications. No clinical trials or approved therapeutic indications exist for this compound. |
| Molecular Formula |
C3H8O2S
|
|---|---|
| Molecular Weight |
108.16
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| Exact Mass |
108.024
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| CAS # |
96-27-5
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| PubChem CID |
7291
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
247.0±0.0 °C at 760 mmHg
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| Flash Point |
126.3±24.6 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.526
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| LogP |
-0.92
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
6
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| Complexity |
32
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OCC(CS)O
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| InChi Key |
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2
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| Chemical Name |
3-sulfanylpropane-1,2-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (924.56 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (23.11 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.2456 mL | 46.2278 mL | 92.4556 mL | |
| 5 mM | 1.8491 mL | 9.2456 mL | 18.4911 mL | |
| 10 mM | 0.9246 mL | 4.6228 mL | 9.2456 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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