| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Lithium dodecyl sulfate does not have a defined pharmacological target. It is an anionic surfactant used to solubilize proteins and lipids in biochemical research. Its mechanism of action is physical: the hydrophobic alkyl chain interacts with hydrophobic regions of proteins and lipids, while the charged sulfate head group interacts with water, leading to the disruption of membranes and the solubilization of membrane proteins.
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|---|---|
| ln Vitro |
In vitro, lithium dodecyl sulfate is used as a detergent in biochemical applications, particularly in the solubilization of membrane proteins and in polyacrylamide gel electrophoresis (PAGE). It is an alternative to sodium dodecyl sulfate (SDS) in applications where sodium ions are undesirable.
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| ln Vivo |
In vivo data for lithium dodecyl sulfate as a therapeutic agent are not available, as the compound is a detergent used for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro biochemical assays, lithium dodecyl sulfate is used as a detergent to solubilize proteins. Standard protocols involve dissolving the compound in an appropriate buffer at a concentration of 0.1-2% (w/v) and adding it to the protein sample. The sample is then heated to denature the proteins, which are subsequently separated by gel electrophoresis.
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| Cell Assay |
For in vitro cell-based experiments, lithium dodecyl sulfate is not typically used directly in cell culture. It is a detergent used for protein extraction and analysis. The compound may be used in the preparation of cell lysates for downstream analyses, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for lithium dodecyl sulfate are not applicable, as the compound is a detergent used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for lithium dodecyl sulfate are not available, as the compound is not a drug and is not administered to living organisms. The compound is a solid and should be stored under appropriate conditions.
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| Toxicity/Toxicokinetics |
Lithium dodecyl sulfate is a research chemical and should be handled with appropriate laboratory safety precautions. As a detergent, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications.
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| References | |
| Additional Infomation |
Lithium dodecyl sulfate (LDS) (CAS 2044-56-6) is primarily a research-grade biochemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are as a detergent for protein solubilization and in polyacrylamide gel electrophoresis.
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| Molecular Formula |
C12H25LIO4S
|
|---|---|
| Molecular Weight |
272.33
|
| Exact Mass |
272.163
|
| CAS # |
2044-56-6
|
| Related CAS # |
151-41-7 (Parent)
|
| PubChem CID |
2735071
|
| Appearance |
White to off-white solid powder
|
| LogP |
4.464
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
18
|
| Complexity |
249
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Li+].CCCCCCCCCCCCOS(=O)(=O)[O-]
|
| InChi Key |
YFVGRULMIQXYNE-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C12H26O4S.Li/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
|
| Chemical Name |
lithium;dodecyl sulfate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (367.20 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.18 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.18 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.18 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6720 mL | 18.3601 mL | 36.7202 mL | |
| 5 mM | 0.7344 mL | 3.6720 mL | 7.3440 mL | |
| 10 mM | 0.3672 mL | 1.8360 mL | 3.6720 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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