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| Other Sizes |
| Targets |
2-Amino-2-methyl-1-propanol does not have a defined pharmacological target. It is a buffering agent used to stabilize pH in biochemical and industrial applications. Its mechanism of action is chemical: the amino group can accept protons, while the hydroxyl group can donate them, allowing the compound to resist changes in pH. It is also used as a surfactant and emulsifier.
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| ln Vitro |
In vitro, 2-amino-2-methyl-1-propanol is used as a buffer and pH stabilizer in a variety of biochemical applications. It is used in electrophoresis, protein purification, and as a component in media formulations. As an amino alcohol, it is also used as a building block in organic synthesis.
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| ln Vivo |
In vivo data for 2-amino-2-methyl-1-propanol as a therapeutic agent are not available, as the compound is primarily used as a buffer and chemical intermediate. It is not intended for therapeutic administration and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro biochemical assays, 2-amino-2-methyl-1-propanol is used as a buffer component. A typical protocol involves preparing a buffer solution at a desired concentration (e.g., 10-100 mM) and adjusting the pH to the required value (e.g., pH 8.0-10.0). This buffer is then used to maintain a stable pH in various applications, such as electrophoresis or enzyme assays.
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| Cell Assay |
For in vitro cell-based experiments, 2-amino-2-methyl-1-propanol is not typically used directly in cell culture. It is a buffer and chemical intermediate used in the preparation of reagents or the synthesis of compounds that may be tested in cell-based assays.
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| Animal Protocol |
In vivo animal studies for 2-amino-2-methyl-1-propanol are not applicable, as the compound is a buffer and chemical intermediate. No animal studies have been conducted for this compound as a therapeutic agent.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
This study investigated the metabolism and distribution of (3)H-labeled 2-amino-2-methylpropanol in rats on normal and choline-deficient diets. Thirty minutes after intraperitoneal injection, tritium was detected in the serum of both groups, but tritium levels were generally lower in the choline-deficient group. The excretion of amino acids in the urine of both normal-diet rats was higher than that of the choline-deficient group, and only unchanged amino acids were excreted. Compared to normal rats, the liver of the choline-deficient group showed higher uptake and retention of the marker. Most of the marker was found in the cytoplasm of the liver and kidneys. Pharmacokinetic data for 2-amino-2-methyl-1-propanol are not available, as the compound is not a drug and is not administered to living organisms. It is a solid with a melting point of 30-32°C and is soluble in water. |
| Toxicity/Toxicokinetics |
Toxicity Summary
This product is safe within its current usage and concentration range. Information on ingredients, concentrations, and usage can be found at: https://cir-reports.cir-safety.org 2-Amino-2-methyl-1-propanol is a research chemical and should be handled with appropriate laboratory safety precautions. As an amine, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications. |
| References | |
| Additional Infomation |
2-Amino-2-methyl-1-propanol is a clear, light-colored liquid, insoluble in water, with a density similar to water, and a flash point of 172°F (78°C). It is used in the manufacture of other chemicals.
2-Amino-2-methyl-1-propanol (AMP) (CAS 124-68-5) is primarily a research-grade chemical intermediate and buffer, not an FDA-approved pharmaceutical drug. Its primary applications are as a buffering agent and pH stabilizer in biochemical research and as a building block in organic synthesis. |
| Molecular Formula |
C4H11NO
|
|---|---|
| Molecular Weight |
89.14
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| Exact Mass |
89.084
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| CAS # |
124-68-5
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| Related CAS # |
2-Amino-2-methylpropan-1-ol hydrochloride;3207-12-3;2-Amino-2-methyl-1-propanol-d11;1435933-80-4
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| PubChem CID |
11807
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| Appearance |
Colorless to light yellow <24°C powder,>28°C liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
167.2±13.0 °C at 760 mmHg
|
| Melting Point |
89.6 °F (USCG, 1999)
; 31 °C
; 31 °C
; 89.6 °F
|
| Flash Point |
67.2±0.0 °C
|
| Vapour Pressure |
0.6±0.7 mmHg at 25°C
|
| Index of Refraction |
1.447
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| LogP |
-0.61
|
| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
6
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| Complexity |
42.8
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C)(N)CO
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| InChi Key |
CBTVGIZVANVGBH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
|
| Chemical Name |
2-amino-2-methylpropan-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (1121.83 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 11.2183 mL | 56.0915 mL | 112.1831 mL | |
| 5 mM | 2.2437 mL | 11.2183 mL | 22.4366 mL | |
| 10 mM | 1.1218 mL | 5.6092 mL | 11.2183 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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