| Size | Price | Stock | Qty |
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| 5g |
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| 10g |
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| 25g |
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| Other Sizes |
| Targets |
3,4,7,8-Tetramethyl-1,10-phenanthroline does not have a defined pharmacological target. It is a bidentate ligand used in coordination chemistry. Its mechanism of action is chemical: the phenanthroline nitrogen atoms coordinate to metal ions to form stable complexes. The methyl groups provide steric and electronic effects that can influence the properties of the metal complexes.
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|---|---|
| ln Vitro |
For use in biological material or organic compound biochemistry, 3,4,7,8-Tetramethyl-1,10-phenanthroline is a biochemical reagent.
In vitro, 3,4,7,8-tetramethyl-1,10-phenanthroline is used as a ligand in coordination chemistry. It is used to form metal complexes for various applications, including catalysis, materials science, and biological studies. As a methylated phenanthroline, it is a common building block for the preparation of metal complexes with tuned properties. |
| ln Vivo |
In vivo activity data for 3,4,7,8-tetramethyl-1,10-phenanthroline are not available, as the compound is a ligand used for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro coordination chemistry, 3,4,7,8-tetramethyl-1,10-phenanthroline is used as a ligand to form metal complexes. Standard protocols involve dissolving the ligand in an appropriate solvent (e.g., ethanol, acetonitrile) and reacting it with a metal salt (e.g., RuCl₃, FeCl₂) to form coordination complexes. The complexes are characterized by UV-Vis spectroscopy, NMR, and mass spectrometry.
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| Cell Assay |
For in vitro cell-based experiments, 3,4,7,8-tetramethyl-1,10-phenanthroline is not typically used directly in cell culture. It is a chemical reagent used for coordination chemistry and organic synthesis. The compound may be used in the synthesis of metal complexes that are subsequently tested in cell-based assays.
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| Animal Protocol |
In vivo animal studies for 3,4,7,8-tetramethyl-1,10-phenanthroline are not applicable, as the compound is a ligand used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 3,4,7,8-tetramethyl-1,10-phenanthroline are not available, as the compound is not a drug and is not administered to living organisms. The compound is a solid and should be stored under appropriate conditions.
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| Toxicity/Toxicokinetics |
3,4,7,8-Tetramethyl-1,10-phenanthroline is a research chemical and should be handled with appropriate laboratory safety precautions. As a nitrogen-containing heterocycle, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications.
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| Additional Infomation |
3,4,7,8-Tetramethyl-1,10-phenanthroline (TMPhen, CAS 1660-93-1) is primarily a research-grade chemical ligand, not an FDA-approved pharmaceutical drug. Its primary application is as a bidentate ligand in coordination chemistry for the formation of metal complexes.
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| Molecular Formula |
C16H16N2
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|---|---|
| Molecular Weight |
236.31
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| Exact Mass |
236.131
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| CAS # |
1660-93-1
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| PubChem CID |
74265
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
435.2±40.0 °C at 760 mmHg
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| Melting Point |
277-280 °C(lit.)
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| Flash Point |
192.6±18.6 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.662
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| LogP |
3.62
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
18
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| Complexity |
274
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N1C([H])=C(C([H])([H])[H])C(C([H])([H])[H])=C2C([H])=C([H])C3=C(C([H])([H])[H])C(C([H])([H])[H])=C([H])N=C3C=12
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| InChi Key |
NPAXPTHCUCUHPT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H16N2/c1-9-7-17-15-13(11(9)3)5-6-14-12(4)10(2)8-18-16(14)15/h5-8H,1-4H3
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| Chemical Name |
3,4,7,8-tetramethyl-1,10-phenanthroline
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol: 50 mg/mL (211.59 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.58 mg/mL (10.92 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.8 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% EtOH + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2317 mL | 21.1586 mL | 42.3173 mL | |
| 5 mM | 0.8463 mL | 4.2317 mL | 8.4635 mL | |
| 10 mM | 0.4232 mL | 2.1159 mL | 4.2317 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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