| Size | Price | |
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| Other Sizes |
| Targets |
Pyridine-2,6-dicarboxylic acid does not have a defined pharmacological target. It is a biochemical reagent used as a chelating agent for metal ions such as chromium, zinc, manganese, copper, iron, and molybdenum. It is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes. Due to its association with bacterial endospores, it is used as a biomarker in microbiological and environmental studies.
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| ln Vitro |
In vitro, pyridine-2,6-dicarboxylic acid is used as a chelating agent and biochemical reagent. It is used in the preparation of metal complexes for various applications. As a dipicolinic acid analog, it is used in studies of bacterial spore detection and identification. It is also used as a building block in organic synthesis.
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| ln Vivo |
In vivo activity data for pyridine-2,6-dicarboxylic acid as a therapeutic agent are not available, as the compound is a biochemical reagent used for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro metal chelation studies, pyridine-2,6-dicarboxylic acid is used as a chelating agent. Standard protocols involve dissolving the compound in an appropriate buffer and adding it to a solution containing metal ions. The formation of metal complexes can be studied using techniques such as UV-Vis spectroscopy, potentiometry, or mass spectrometry.
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| Cell Assay |
For in vitro cell-based experiments, pyridine-2,6-dicarboxylic acid is not typically used directly in cell culture. It is a biochemical reagent used for metal chelation and organic synthesis. The compound may be used in the preparation of metal complexes or other compounds that are subsequently tested in cell-based assays.
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| Animal Protocol |
In vivo animal studies for pyridine-2,6-dicarboxylic acid are not applicable, as the compound is a biochemical reagent used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for pyridine-2,6-dicarboxylic acid are not available, as the compound is not a drug and is not administered to living organisms. It is a solid and should be stored under appropriate conditions.
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| Toxicity/Toxicokinetics |
Pyridine-2,6-dicarboxylic acid is a research chemical and should be handled with appropriate laboratory safety precautions. As a carboxylic acid, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications.
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| Additional Infomation |
Dipyridine acid is a pyridine dicarboxylic acid with two carboxyl groups at positions 2 and 6. It is a bacterial metabolite and the conjugate acid of dipyridine carboxylate (1-). It has been reported that 2,6-pyridine dicarboxylic acid is present in Cordyceps militaris, Penicillium picorisum, and Streptomyces coccidioides, and relevant data are available.
Pyridine-2,6-dicarboxylic acid (2,6-Pyridinedicarboxylic acid, CAS 499-83-2) is primarily a research-grade biochemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are as a chelating agent for metal ions, in the preparation of metal complexes, and as a biomarker for bacterial spores in environmental studies. |
| Molecular Formula |
C7H5NO4
|
|---|---|
| Molecular Weight |
167.12
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| Exact Mass |
167.021
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| CAS # |
499-83-2
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| Related CAS # |
17956-40-0 (di-hydrochloride salt);4220-17-1 (mono-hydrochloride salt);63450-91-9 (di-potassium salt)
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| PubChem CID |
10367
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| Appearance |
White to off-white solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
463.7±30.0 °C at 760 mmHg
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| Melting Point |
252 °C
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| Flash Point |
234.3±24.6 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.628
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| LogP |
-0.83
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
12
|
| Complexity |
184
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C(C1C([H])=C([H])C([H])=C(C(=O)O[H])N=1)=O
|
| InChi Key |
WJJMNDUMQPNECX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-5(8-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
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| Chemical Name |
pyridine-2,6-dicarboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (598.37 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.96 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.96 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.96 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.9837 mL | 29.9186 mL | 59.8372 mL | |
| 5 mM | 1.1967 mL | 5.9837 mL | 11.9674 mL | |
| 10 mM | 0.5984 mL | 2.9919 mL | 5.9837 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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